PAD4-IN-3
PAD4-IN-3 (compound 4B) is a PAD4 inhibitor with antitumor activity in vitro and in vivo. PAD4-IN-3 was covalently linked to RGD sequence peptide-modified chitosan (K-CRGDV), resulting in an enhanced oxidative stress-responsive nanoagent. K-CRGDV-PAD4-IN-3 can actively target tumors, inhibit PAD4 activity, block the formation of neutrophil extracellular traps (NETs), and improve the tumor immune microenvironment in response to the tumor microenvironment.
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- CAS No.: 2642327-44-2
- Formule: C21H26BClN4O4
- Masse moléculaire:444.72
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
PAD4[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 4T1 | IC50 |
>100 μM
Compound: 5a
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Cytotoxicity against mouse 4T1 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against mouse 4T1 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
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[PMID: 37421890] |
Chemical Information
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CAS No. 2642327-44-2
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Masse moléculaire 444.72
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Formule C21H26BClN4O4
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SMILES
O=C(NCC1=CC=CC=C1)[C@H](CCCNC(CCl)=N)NC(C2=CC(B(O)O)=CC=C2)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PAD4-IN-3 Related Classifications
HY-157157 Related Classifications
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