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Cat. No.: HY-163148

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PHD-IN-3

PHD-IN-3 (Compound 15) is an orally active PHD inhibitor. PHD-IN-3 can be used in the study of anemia associated with chronic kidney disease.

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CAS No.: 2924181-77-9
Formule: C₂₀H₁₈N₆O₃
Masse moléculaire:390.40

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

PHD-IN-3 Chemical Structure

CAS No.: 2924181-77-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

PHD-IN-3 (Compound 15) is an orally active PHD inhibitor. PHD-IN-3 can be used in the study of anemia associated with chronic kidney disease^[1].

Voir tous les produits spécifiques à Isoform HIF/HIF Prolyl-Hydroxylase :

Cellular Effect

Cell Line	Type	Value	Description	References
Hep 3B2	EC₅₀	5 μM Compound: 15	Upregulation of total HIF-1alpha level in human Hep3B cells incubated for 6 hrs by Western blot analysis Upregulation of total HIF-1alpha level in human Hep3B cells incubated for 6 hrs by Western blot analysis	[PMID: 38189253]
Hep 3B2	EC₅₀	6.8 μM Compound: 15	Induction of EPO production in human Hep3B cells incubated for 24 hrs by ELISA Induction of EPO production in human Hep3B cells incubated for 24 hrs by ELISA	[PMID: 38189253]
Hep 3B2	EC₅₀	9 μM Compound: 15	Upregulation of total HIF-2alpha level in human Hep3B cells incubated for 6 hrs by Western blot analysis Upregulation of total HIF-2alpha level in human Hep3B cells incubated for 6 hrs by Western blot analysis	[PMID: 38189253]
Hep 3B2	IC₅₀	>100 μM Compound: 15	Cytotoxicity against human Hep3B cells by CellTiter-Glo assay Cytotoxicity against human Hep3B cells by CellTiter-Glo assay	[PMID: 38189253]

Chemical Information

CAS No. 2924181-77-9
Masse moléculaire 390.40
Formule C₂₀H₁₈N₆O₃
SMILES

O[C@@H]1CCN(C1)C2=NC3=C(C(O)=C(N=C3)C(NCC4=CN=C(C=C4)C#N)=O)C=C2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Xu J, et al. Discovery of Novel and Potent Prolyl Hydroxylase Domain-Containing Protein (PHD) Inhibitors for The Treatment of Anemia. J Med Chem. 2024 Jan 8. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

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Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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PHD-IN-3

Voir tous les produits spécifiques à Isoform HIF/HIF Prolyl-Hydroxylase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

PHD-IN-3 Related Classifications

HY-163148 Related Classifications