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Rapirosiran

(Synonyms: ALN-HSD; ALN-288996; AD-288996)

Rapirosiran (ALN-HSD) is a HSD17β13-targeting siRNA. Rapirosiran can be used for the research of metabolic dysfunction-associated steatohepatitis.

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  • Rapirosiran Chemical Structure
    Rapirosiran Chemical Structure
CAS No.: 2755196-97-3
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  • Rapirosiran Chemical Structure
    Rapirosiran Chemical Structure RNA, (Am-sp-(2′-deoxy-2′-fluoro)G-sp-Am-Um-Am-Gm-(3′→3′)-[1-de-β-D-ribofuranosyl-1-[(2S)-2,3-dihydroxypropyl]]m5U-(2′→5′)-Cm-Cm-Am-Um-Gm-Cm-(2′-deoxy-2′-fluoro)A-Am-(2′-deoxy-2′-fluoro)A-Am-Gm-Cm-Am-Um-sp-Um-sp-Cm), complex with RNA (Am-sp-Um-sp-Gm-Cm-Um-Um-(2′-deoxy-2′-fluoro)U-Um-(2′-deoxy-2′-fluoro)G-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)A-Um-Gm-Gm-Am-Cm-Um-Am-Um-Cm-Um) 3′-[[(2S,4R)-1-[29-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-1,12,19,25-tetraoxo-16-oxa-13,20,24-triazanonacos-1-yl]-4-hydroxy-2-pyrrolidinyl]methyl hydrogen phosphate] (1:1)
    1/16
  • RNA, (Am-sp-(2′-deoxy-2′-fluoro)G-sp-Am-Um-Am-Gm-(3′→3′)-[1-de-β-D-ribofuranosyl-1-[(2S)-2,3-dihydroxypropyl]]m5U-(2′→5′)-Cm-Cm-Am-Um-Gm-Cm-(2′-deoxy-2′-fluoro)A-Am-(2′-deoxy-2′-fluoro)A-Am-Gm-Cm-Am-Um-sp-Um-sp-Cm), complex with RNA (Am-sp-Um-sp-Gm-Cm-Um-Um-(2′-deoxy-2′-fluoro)U-Um-(2′-deoxy-2′-fluoro)G-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)A-Um-Gm-Gm-Am-Cm-Um-Am-Um-Cm-Um) 3′-[[(2S,4R)-1-[29-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-1,12,19,25-tetraoxo-16-oxa-13,20,24-triazanonacos-1-yl]-4-hydroxy-2-pyrrolidinyl]methyl hydrogen phosphate] (1:1)