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Cat. No.: HY-W706573

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(S)-(-)-Nitrendipine

Name: (S)-(-)-Nitrendipine
Brand: MedChemExpress
SKU: HY-W706573
Availability: PreOrder

(Synonyms: (S)-(-)-BAY-E-5009)

(S)-(-)-Nitrendipine ((S)-(-)-BAY-E-5009) is an isomer of Nitrendipine (HY-B0424). Nitrendipine acts as a calcium channel blocker. (S)-(-)-Nitrendipine can be used for research on hypertension.

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CAS No.: 80873-62-7
Formule: C₁₈H₂₀N₂O₆
Masse moléculaire:360.36

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(S)-(-)-Nitrendipine Chemical Structure

CAS No.: 80873-62-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

(S)-(-)-Nitrendipine ((S)-(-)-BAY-E-5009) is an isomer of Nitrendipine (HY-B0424). Nitrendipine acts as a calcium channel blocker. (S)-(-)-Nitrendipine can be used for research on hypertension^[1].

Chemical Information

CAS No. 80873-62-7
Masse moléculaire 360.36
Formule C₁₈H₂₀N₂O₆
SMILES

CCOC(C1=C(C)NC(C)=C(C(OC)=O)[C@@H]1C2=CC([N+]([O-])=O)=CC=C2)=O
Synonyms

(S)-(-)-BAY-E-5009
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Signal Pathway Related

Research Protocol for Cardiovascular Diseases
Cardiovascular disease can be modeled as maladaptive cardiac remodeling, where ischemic injury or pressure overload activates inflammatory signaling, fibroblast activation, extracellular-matrix deposition, cardiomyocyte hypertrophy, vascular remodeling, and progressive ventricular dysfunction. The TGF-β/SMAD axis is a central profibrotic pathway after myocardial injury and pressure overload, while innate immune and cytokine pathways regulate leukocyte recruitment, scar formation, and adverse remodeling. Key unresolved questions include which inflammatory signals are reparative versus harmful, when fibrosis is protective versus maladaptive, and whether pathway inhibition improves function without weakening necessary infarct healing or compensatory remodeling.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Soons PA, et al. Stereoselective pharmacokinetics of oral and intravenous nitrendipine in healthy male subjects. British journal of clinical pharmacology. 1991 Jul;32(1):11-6. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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