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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
hNET
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "hNET" in MCE Product Catalog:
Cat. No.: HY-B0602
CAS No.: 93413-62-8
Synonyms: O-Desmethylvenlafaxine
Domaines de recherche:
Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter .
Cat. No.: HY-B0602A
CAS No.: 386750-22-7
Synonyms: O-Desmethylvenlafaxine succinate hydrate
Target:
Domaines de recherche:
Desvenlafaxine succinate hydrate, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine succinate hydrate shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter .
Cat. No.: HY-18332C
CAS No.: 66504-40-3
Domaines de recherche:
DOV-216,303 (Free Base) is a potent triple serotonin, norepinephrine, and dopamine reuptake inhibitor, with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. Has antidepressant-like effects and increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats .
Cat. No.: HY-B0602S2
CAS No.: 1062605-69-9
Cat. No.: HY-10427A
CAS No.: 1214914-38-1
Synonyms: iso-NRI-022
Domaines de recherche:
iso-WAY-260022 (Compound 13R) is an orally active, brain-penetrant and selective norepinephrine transporter (hNET) inhibitor with an IC50 value of 140 nM. iso-WAY-260022 also shows inhibitory effects on human serotonin (hSERT) and dopamine transporters (hDAT). iso-WAY-260022 inhibits norepinephrine reuptake and increases hypothalamic norepinephrine levels to regulate thermoregulatory center function. iso-WAY-260022 is promising for research of vasomotor symptoms, such as menopausal hot flushes, night sweats .
Cat. No.: HY-161913
Target:
Domaines de recherche:
AC-4-248 is an atypical non-competitive dopamine transporter (DAT) inhibitor and reduces the potency of cocaine to inhibit DAT. AC-4-248 is a non-selective inhibitor of SLC6 transporters with IC50 values for hDAT, hSERT, and hNET of 45.5 μM, 96.2 μM, and 250 μM, respectively .
Cat. No.: HY-W061043
CAS No.: 86215-36-3
Domaines de recherche:
DOV-216,303 is an antidepressant compound. DOV-216,303 inhibits the reuptake of norepinephrine (NE), serotonin (5‐HT), and dopamine (DA), with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. DOV-216,303 increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats .
Cat. No.: HY-16170
CAS No.: 448904-47-0
Synonyms: O-Desmethylvenlafaxine succinate; Wy-45233 succinate
Target:
Domaines de recherche:
Desvenlafaxine succinate, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine succinate (DVS) shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter .
Cat. No.: HY-B0602S3
CAS No.: 1062607-49-1
Cat. No.: HY-B0602R
CAS No.: 93413-62-8
Synonyms: O-Desmethylvenlafaxine (Standard)
Domaines de recherche:
Desvenlafaxine (Standard) is the analytical standard of Desvenlafaxine. This product is intended for research and analytical applications. Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter .
Cat. No.: HY-N2426R
CAS No.: 119738-57-7
Cat. No.: HY-W1133231
CAS No.: 1879038-73-9
Target:
Domaines de recherche:
CE-103 is a selective, blood-brain barrier-permeable dopamine transporter (DAT) inhibitor with an IC50 of 14.73 μM. CE-103 blocks DAT-mediated dopamine reuptake and exhibits antagonistic activity against 5-HT1A. CE-103 reduces working memory errors in the radial arm maze test of rats, decreases the levels of complexes containing phosphorylated DAT (pDAT) and D1R in the hippocampus of rats, and increases the levels of complexes containing D2R and D3R simultaneously. CE-103 can be used in studies related to dopaminergic neurotransmission, working memory and cognitive function .
Cat. No.: HY-182247
CAS No.: 1632000-05-5
Domaines de recherche:
D-473 is an orally active, blood-brain barrier penetrant and serotonin-preferring reuptake inhibitor. D-473 inhibits serotonin, dopamine and norepinephrine transporters, and significantly elevates the extracellular levels of these three neurotransmitters in rat brain regions. D-473 exhibits definite antidepressant-like activity without inducing motor activation. D-473 is widely used in studies related to major depressive disorder .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
