86215-36-3
86215-36-3
Chemical Structure
DOV-216,303
- CAS No.: 86215-36-3
- Formula:C11H12Cl3N
- Molecular Weight:264.58
IUPAC Name: 1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane hydrochloride
InChIKey: KAGBHVBIOJBGBD-UHFFFAOYSA-N
SMILES: ClC1=C(C=C(C23CC2CNC3)C=C1)Cl.Cl
Biological Activity: DOV-216,303 is an antidepressant compound. DOV-216,303 inhibits the reuptake of norepinephrine (NE), serotonin (5‐HT), and dopamine (DA), with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. DOV-216,303 increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats[1][2][3].
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DOV-216,303 | DOV-216,303 is an antidepressant compound. DOV-216,303 inhibits the reuptake of norepinephrine (NE), serotonin (5‐HT), and dopamine (DA), with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. DOV-216,303 increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats. | |||||||||||||||||||||
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References
- [1]. Skolnick P, et al. Preclinical and clinical pharmacology of DOV 216,303, a "triple" reuptake inhibitor. CNS Drug Rev. 2006 Summer;12(2):123-34. [Content Brief]
- [2]. Shao L, et al. Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1438-41. [Content Brief]
- [3]. Prins J, et al. The putative antidepressant DOV 216,303, a triple reuptake inhibitor, increases monoamine release in the prefrontal cortex of olfactory bulbectomized rats. Eur J Pharmacol. 2010 May 10;633(1-3):55-61. [Content Brief]
Keywords
