SIB-1281
SIB-1281 is a β-secretase inhibitor that inhibits β-site cleavage of amyloid precursor protein (APP) and reduces the production of Aβ peptides. SIB-1281 decreases the generation of Aβ40 and Aβ42, and promotes the secretion of α-sAPP. SIB-1281 can be used in studies related to Alzheimer's disease.
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- CAS No.: 181139-85-5
- Formule: C26H39N3O5
- Masse moléculaire:473.60
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
In Vitro
SIB-1281 inhibits Aβ40 and Aβ42 production with an IC50 of 800 nM, potentiates α-sAPP secretion with an EC50 of 650 nM, and does not alter APP holoprotein levels in human glioblastoma cells transfected with wild-type or mutant APP695 cDNAs[1].
SIB-1281 (16 h) inhibits over 95% of all measured Aβ peptide variant production and increases α-sAPP secretion by ~10-fold in human glioblastoma cells stably expressing Swedish/Indiana mutant APP[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 181139-85-5
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Masse moléculaire 473.60
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Formule C26H39N3O5
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SMILES
O=C(OCC1=CC=CC=C1)N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C=O)CC(C)=C)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SIB-1281 Related Classifications
HY-187132 Related Classifications
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