SPDZi1
SPDZi1 is a potent and selective syntenin inhibitor that binds to PDZ1 and PDZ2 domains of syntenin. SPDZi1 binds to the syntenin PDZ tandem (STNPDZ) with a Kd of 3.6 μM. SPDZi1 suppresses glioblastoma and reduces the activation of NF-κB, a downstream effector of syntenin.
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- Formule: C22H19N3O5
- Masse moléculaire:405.40
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
SPDZi1 (Z3322068027; 20 μM; 24 h) inhibits human glioblastoma multiforme (GBM) cell proliferation while concurrently reducing the activation of NF-κB[1].
In glioblastoma organoids (GBOs), SPDZi1 effectively suppresses the growth of small GBOs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U87-MG
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Concentration:20 μM
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Incubation Time:24 h
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Result:Demonstrated a profound inhibitory effect on human GBM cell proliferation.
Chemical Information
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Masse moléculaire 405.40
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Formule C22H19N3O5
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SMILES
O=C(N[C@@H](CC(N1)=NC=CC1=O)C(O)=O)OCC(C2=C3C=CC=C2)C4=C3C=CC=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SPDZi1 Related Classifications
HY-162510 Related Classifications
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