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Cat. No.: HY-182672

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VT101

VT101 is a TEAD inhibitor with an IC₅₀ of 454 nM. VT101 is applicable for cancer research.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 65194-64-1
Formule: C₁₄H₂₀N₂O₄S
Masse moléculaire:312.38

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Please store the product under the recommended conditions in the Certificate of Analysis.

VT101 Chemical Structure

CAS No.: 65194-64-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

VT101 is a TEAD inhibitor with an IC₅₀ of 454 nM. VT101 is applicable for cancer research^[1].

IC₅₀ & Target^[1]

TEAD

454 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform YAP :

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H2052	IC₅₀	3 μM Compound: 39; VT101	Antiproliferative activity against human NCI-H2052 cells Antiproliferative activity against human NCI-H2052 cells	[PMID: 39047607]

In Vitro

VT101 inhibits YAP-mediated transcriptional activity with an IC₅₀ of 454 nM in a luciferase reporter assay but does not significantly inhibit the growth of NCI-H2052 cells (IC₅₀ > 3 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 65194-64-1
Masse moléculaire 312.38
Formule C₁₄H₂₀N₂O₄S
SMILES

O=C(C1=CC(S(=O)(N)=O)=CC=C1NC2CCCCC2)OC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Lou J, et al. A chemical perspective on the modulation of TEAD transcriptional activities: Recent progress, challenges, and opportunities. Eur J Med Chem. 2022;243:114684. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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VT101

Voir tous les produits spécifiques à Isoform YAP

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

VT101 Related Classifications

HY-182672 Related Classifications