2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. Chlorisondamine diiodide

Chlorisondamine (diiodide) is a potent nicotinic acetylcholine receptor (nAChR) antagonist and a ganglion blocker. Chlorisondamine antagonizes some of nicotine's central actions in a potent, long-lasting and pharmacologically selective way.

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Chlorisondamine diiodide Chemical Structure

Chlorisondamine diiodide Chemical Structure

CAS No. : 96750-66-2

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Based on 1 publication(s) in Google Scholar

Chlorisondamine diiodide Related Antibodies

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Description

Chlorisondamine (diiodide) is a potent nicotinic acetylcholine receptor (nAChR) antagonist and a ganglion blocker. Chlorisondamine antagonizes some of nicotine's central actions in a potent, long-lasting and pharmacologically selective way[1].

IC50 & Target

nAChR[1]
In Vivo

Chlorisondamine (0.2, 1.0, 5.0 μg; IV; single dosage) antagonizes the depressant action of nicotine on vertical activity (0-20min) in a dose-dependent way at 1 and 2 weeks[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats (treated once with nicotine 0.4 mg/kg, s.c.)[1]
Dosage: 0.2, 1.0, 5.0 μg
Administration: IV; single dosage
Result: Antagonized the depressant action of nicotine on vertical activity (0-20min) in a dose-dependent way at 1 and 2 weeks.
Molecular Weight

611.94

Formula

C14H20Cl4I2N2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[N+](CC[N+]1(C)CC2=C(C(Cl)=C(Cl)C(Cl)=C2Cl)C1)(C)C.[I-].[I-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (16.34 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6341 mL 8.1707 mL 16.3415 mL
5 mM 0.3268 mL 1.6341 mL 3.2683 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (248 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6341 mL 8.1707 mL 16.3415 mL 40.8537 mL
5 mM 0.3268 mL 1.6341 mL 3.2683 mL 8.1707 mL
10 mM 0.1634 mL 0.8171 mL 1.6341 mL 4.0854 mL
15 mM 0.1089 mL 0.5447 mL 1.0894 mL 2.7236 mL
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Chlorisondamine diiodide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chlorisondamine diiodide96750-66-2nAChRNicotinic acetylcholine receptorsVertical activityRatNicotineInhibitorinhibitorinhibit

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