1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. Chlorisondamine diiodide

Chlorisondamine diiodide 

Cat. No.: HY-101347
Handling Instructions

Chlorisondamine (diiodide) is a potent nicotinic acetylcholine receptor (nAChR) antagonist and a ganglion blocker. Chlorisondamine antagonizes some of nicotine's central actions in a potent, long-lasting and pharmacologically selective way.

For research use only. We do not sell to patients.

Chlorisondamine diiodide Chemical Structure

Chlorisondamine diiodide Chemical Structure

CAS No. : 96750-66-2

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Description

Chlorisondamine (diiodide) is a potent nicotinic acetylcholine receptor (nAChR) antagonist and a ganglion blocker. Chlorisondamine antagonizes some of nicotine's central actions in a potent, long-lasting and pharmacologically selective way[1].

IC50 & Target

nAChR[1]

In Vivo

Chlorisondamine (0.2, 1.0, 5.0 μg; IV; single dosage) antagonizes the depressant action of nicotine on vertical activity (0-20min) in a dose-dependent way at 1 and 2 weeks[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats (treated once with nicotine 0.4 mg/kg, s.c.)[1]
Dosage: 0.2, 1.0, 5.0 μg
Administration: IV; single dosage
Result: Antagonized the depressant action of nicotine on vertical activity (0-20min) in a dose-dependent way at 1 and 2 weeks.
Molecular Weight

611.94

Formula

C14H20Cl4I2N2

CAS No.
SMILES

C[N+](CC[N+]1(C)CC2=C(C(Cl)=C(Cl)C(Cl)=C2Cl)C1)(C)C.[I-].[I-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
Chlorisondamine diiodide
Cat. No.:
HY-101347
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