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Cat. No.: HY-156087

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Cholicamideβ

Cholicamideβ (GMP) is a GMP grade of Cholicamideβ. Cholicamideβ (compound 6) is a self-assembling, small molecule, cancer vaccine adjuvant. Cholicamideβ can form virus-like particles with low cytotoxicity. Cholicamideβ, upon binding to peptide antigens, enhances antigen presentation by dendritic cells and induces antigen-specific T cells. Cholicamideβ can induce apoptosis and necrosis.

For research use only. We do not sell to patients.

CAS No.: 3036578-71-6
Formula: C₅₅H₉₄N₂O₆
Molecular Weight:879.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Cholicamideβ Chemical Structure

CAS No.: 3036578-71-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

Cholicamideβ (compound 6) (4-16 μM; 22 h) induces apoptosis and necrosis in RAW264.7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cholicamideβ (compound 6) (100 μg/mouse; tested after 16 h and 21 d) shows low toxicity and increases HA-specific IgG antibody titers in C57BL/6 mice immunized with split influenza vaccine^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 3036578-71-6
Molecular Weight 879.34
Formula C₅₅H₉₄N₂O₆
SMILES

[H][C@]12C[C@@H]([C@@]3([C@H](CC[C@]3([C@]1([H])CC[C@@]4(C[C@@H](CC[C@]24C)O)[H])[H])[C@@H](CCC(NCCCCCCCNC(CC[C@H]([C@@H]5[C@@]6(C)[C@@H](O)C[C@@]7([H])[C@@](CC[C@@]8(C[C@@H](CC[C@@]87C)O)[H])([C@@]6(CC5)[H])[H])C)=O)=O)C)C)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhuo SH, et al. Identification of a Self-Assembling Small-Molecule Cancer Vaccine Adjuvant with an Improved Toxicity Profile. J Med Chem. 2023 Sep 7.. . [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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