Chrodrimanin B
Chrodrimanin B, a metabolite of a fungal, is a potent, non-open-channel-blocking antagonist on?B.?mori GABAR RDL with an IC50?of 1.13 nM. Chrodrimanin B attenuates the peak current amplitude of the GABA response of RDL with an IC50?of 1.66 nM.?Chrodrimanin B, a meroterpenoid, shows insecticidal activity.
For research use only. We do not sell to patients.
- CAS No.: 132196-54-4
- Formula: C27H32O8
- Molecular Weight:484.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>50 μM
Compound: 5
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Cytotoxicity against human A549 cells by sulforhodamine B assay
Cytotoxicity against human A549 cells by sulforhodamine B assay
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[PMID: 26046820] |
| HeLa | IC50 |
>50 μM
Compound: 5
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Cytotoxicity against human HeLa cells by sulforhodamine B assay
Cytotoxicity against human HeLa cells by sulforhodamine B assay
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[PMID: 26046820] |
| HL-60 | IC50 |
>50 μM
Compound: 5
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Cytotoxicity against human HL60 cells by sulforhodamine B assay
Cytotoxicity against human HL60 cells by sulforhodamine B assay
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[PMID: 26046820] |
| K562 | IC50 |
>50 μM
Compound: 5
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Cytotoxicity against human K562 cells by sulforhodamine B assay
Cytotoxicity against human K562 cells by sulforhodamine B assay
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[PMID: 26046820] |
| MDCK | IC50 |
55 μM
Compound: 5
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Antiviral activity against influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in MDCK cells incubated for 48 hrs assessed as inhibition of virus-induced cytopathic effect by crystal violet staining assay
Antiviral activity against influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in MDCK cells incubated for 48 hrs assessed as inhibition of virus-induced cytopathic effect by crystal violet staining assay
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[PMID: 26046820] |
In Vitro
Chrodrimanin B exhibits much weaker blocking action on human α1β2γ2 GABAR compared to RDL (IC50=1.48 μM)[1].
Chrodrimanin B shows competitive actions at low concentrations and non-competitive actions at higher concentrations on?B.?mori GABAR RDL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 132196-54-4
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Molecular Weight 484.54
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Formula C27H32O8
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SMILES
C[C@@]([C@@](C(C)1C)([H])C[C@@H]2O)(C=CC1=O)[C@@](CC3=C([C@H]([C@H]4C)OC(C)=O)C(C(O4)=O)=C5O)([H])[C@]2(OC3=C5)C
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Structure Classification
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Initial Source
Aspergillus sp.
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Chrodrimanin B Related Classifications
HY-N8472 Related Classifications
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