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Cat. No.: HY-N21737

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Colocynthoside A

Colocynthoside A is a cucurbitane-type triterpenoid. Colocynthoside A is found in the fruits of Citrullus colocynthis. Colocynthoside A does not inhibit AChE. Colocynthoside A can be used for research on Alzheimer's disease.

For research use only. We do not sell to patients.

CAS No.: 903588-40-9
Formula: C₃₈H₅₄O₁₄
Molecular Weight:734.84

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Colocynthoside A Chemical Structure

CAS No.: 903588-40-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Colocynthoside A does not significantly inhibit AChE, exhibiting an IC₅₀ greater than 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 903588-40-9
Molecular Weight 734.84
Formula C₃₈H₅₄O₁₄
SMILES

C[C@]12[C@]3([C@](C)([C@]4(C(=C[C@@H]3O)C(C)(C)C(=O)C(O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)=C4)[H])C(=O)C[C@]1(C)[C@@]([C@@](C(/C=C/C(OC(C)=O)(C)C)=O)(C)O)([C@H](O)C2)[H])[H]
Structure Classification
- Terpenoids
- Tetracyclic Triterpenoids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Animals and Diseases

Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lima E, et al. Terpenes as potential anti-Alzheimer’s disease agents. Applied Sciences. 2024 May 2;14(9):3898.

[2]. Akanji OC, et al. Evaluation of laxative activity of aqueous extract of Citrullus colocynthis (L.) Schrad. fruits on mice.

[3]. Yoshikawa M, et al. Bioactive saponins and glycosides. XXVII. Structures of new cucurbitane-type triterpene glycosides and antiallergic constituents from Citrullus colocynthis. Chemical & pharmaceutical bulletin. 2007 Mar;55(3):428-34. [Content Brief]

[4]. Gacem MA, et al. Phytochemistry, Toxicity and Pharmacology of Pistacia lentiscus, Artemisia herba-alba and Citrullus colocynthis. InSustainable Agriculture Reviews 39 2020 Apr 30 (pp. 57-93). Cham: Springer International Publishing.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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