2. PROTAC
  3. Ligands for E3 Ligase
  4. CRBN ligand-9

CRBN ligand-9 (Compound 4d) is a CRBN ligand (Ki: 8.9 μM). CRBN ligand-9 can be used for synthesis of PROTACs.

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CRBN ligand-9

CRBN ligand-9 화학구조

CAS No. : 55003-81-1

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
100 mg 해외재고보유
250 mg 해외재고보유
1 g 해외재고보유
5 g   견적 받기  
10 g   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

CRBN ligand-9 Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B KLHL41

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

CRBN ligand-9 (Compound 4d) is a CRBN ligand (Ki: 8.9 μM). CRBN ligand-9 can be used for synthesis of PROTACs[1][2].

IC50 & Target

Cereblon

 

분자량

303.23

화학식

C13H9N3O6
CAS No.
Appearance

Solid

Color

Off-white to gray

SMILES

O=C1NC(CCC1N2C(C3=CC=C(C=C3C2=O)[N+](=O)[O-])=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : ≥ 100 mg/mL (329.78 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2978 mL 16.4891 mL 32.9783 mL
5 mM 0.6596 mL 3.2978 mL 6.5957 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서

Purity: 98.0%

SDS (392 KB)

COA (249 KB) HNMR (131 KB) LCMS (92 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2978 mL 16.4891 mL 32.9783 mL 82.4457 mL
5 mM 0.6596 mL 3.2978 mL 6.5957 mL 16.4891 mL
10 mM 0.3298 mL 1.6489 mL 3.2978 mL 8.2446 mL
15 mM 0.2199 mL 1.0993 mL 2.1986 mL 5.4964 mL
20 mM 0.1649 mL 0.8245 mL 1.6489 mL 4.1223 mL
25 mM 0.1319 mL 0.6596 mL 1.3191 mL 3.2978 mL
30 mM 0.1099 mL 0.5496 mL 1.0993 mL 2.7482 mL
40 mM 0.0824 mL 0.4122 mL 0.8245 mL 2.0611 mL
50 mM 0.0660 mL 0.3298 mL 0.6596 mL 1.6489 mL
60 mM 0.0550 mL 0.2748 mL 0.5496 mL 1.3741 mL
80 mM 0.0412 mL 0.2061 mL 0.4122 mL 1.0306 mL
100 mM 0.0330 mL 0.1649 mL 0.3298 mL 0.8245 mL
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CRBN ligand-9 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRBN ligand-955003-81-1CRBN ligand9CRBN ligand 9Ligands for E3 LigaseE3 ligase-recruiting MoietyCRBN ligandPROTACsInhibitorinhibitorinhibit

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Inquiry Information

상품명:
CRBN ligand-9
Cat. No.:
HY-W342590
수량:
MCE Japan Authorized Agent:

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SAFETY DATA SHEET (SDS)

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