477-29-2
Chemical Structure
Colchicoside
- CAS. Nr.: 477-29-2
- Formula:C27H33NO11
- Molecular Weight:547.55
IUPAC Name: N-((S)-1,2,10-trimethoxy-9-oxo-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide
InChIKey: UXAFRQPVHYZDED-ZZEDUEFDSA-N
SMILES: CC(N[C@H](C1=C2)CCC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=C(OC)C(OC)=C3C1=CC=C(OC)C2=O)=O
Biological Activity: Colchicoside is a monoglycosylated colchicine alkaloid glycoside with anti-leishmanial activity. Colchicoside can be obtained by specific glycosylation of Colchicine (HY-16569) by Astragalus vesicarius plant suspension cells, and is also found in Gloriosa superba seeds. Colchicoside can serve as a precursor for the synthesis of Thiocolchicoside (HY-N0301). Colchicoside can be used in research related to anti-leishmanial infection[1][2][3].
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Colchicoside | 99.37% | Colchicoside is a monoglycosylated colchicine alkaloid glycoside with anti-leishmanial activity. Colchicoside can be obtained by specific glycosylation of Colchicine (HY-16569) by Astragalus vesicarius plant suspension cells, and is also found in Gloriosa superba seeds. Colchicoside can serve as a precursor for the synthesis of Thiocolchicoside (HY-N0301). Colchicoside can be used in research related to anti-leishmanial infection. | ||||||||||||||||||||
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References
- [1]. Zarev Y, et al. Biotransformation to Produce the Anticancer Compound Colchicoside Using Cell Suspension Cultures of Astragalus vesicarius Plant Species. Pharmaceutical Biology, 2019, 14(1): 108.
- [2]. Joshi C S, et al. Isolation and anti-inflammatory activity of colchicinoids from Gloriosa superba seeds. Pharmaceutical Biology, 2010, 48(2): 206-209.
- [3]. Azadbakht M, et al. Tropolone alkaloids from Colchicum kurdicum (Bornm.) Stef. (Colchicaceae) as the potent novel antileishmanial compounds; purification, structure elucidation, antileishmanial activities and molecular docking studies. Exp Parasitol. 2020 Jun;213:107902. [Content Brief]
