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Art. -Nr.: HY-163407

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Galectin-3-IN-4

Galectin-3-IN-4 (compound 5) is a carboxamide analog. Galectin-3-IN-4 is a potent, selective, and orally bioavailable inhibitor of human and mouse galectin-3, with IC₅₀ values of 21 and 167 nM for hGal-3 and mGal-3, respectively. Galectin-3-IN-4 has IC₅₀ values of 1580 and 2750 nM for hGal-1 and hGal-9, respectively.

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CAS. Nr.: 2496515-38-7
Formel: C₂₄H₂₂ClF₂N₅O₅S
Molecular Weight:565.98

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Galectin-3-IN-4 Chemical Structure

CAS. Nr.: 2496515-38-7

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Galectin-3

21 nM (IC₅₀, hGal-3)

Galectin-3

167 nM (IC₅₀, mGal-3)

Galectin-1

1580 nM (IC₅₀, hGal-1)

Alle Galectin Isoform-spezifische Produkte anzeigen :

In Vivo

Galectin-3-IN-4 (compound 5) (2 mg/kg IV, 10 mg/kg PO; once) has a low clearance rate (CL = 12 mL/min/kg) and a high volume of distribution (Vss = 2.1 L/kg), and has a 52 % oral bioavailabilities in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2496515-38-7
Molecular Weight 565.98
Formel C₂₄H₂₂ClF₂N₅O₅S
SMILES

CO[C@@H]1[C@@H](N2C=C(C3=C(C(F)=C(C=C3)Cl)F)N=N2)[C@H]([C@H](O[C@H]1C(N(C4=CC=C(N=CS5)C5=C4)C)=O)CO)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Liu C, et al. Identification of benzothiazole derived monosaccharides as potent, selective, and orally bioavailable inhibitors of human and mouse galectin-3; a rare example of using a S···O binding interaction for drug design. Bioorg Med Chem. 2024 Mar 1;101:117638. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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Galectin-3-IN-4

Alle Galectin Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Galectin-3-IN-4 Related Classifications

HY-163407 Related Classifications