Slc5a2 - solute carrier family 5 (sodium/glucose cotransporter), member 2 Gene

Also Known as Sglt2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 246787

About Slc5a2

Chromosome 7: 127,864,829-127,871,602 forward strand.GRCm39:CM001000.3

This gene has 12 transcripts (splice variants), 200 orthologues, 13 paralogues and is associated with 37 phenotypes. Biased expression in kidney adult (RPKM 372.3) and adrenal adult (RPKM 11.1).

Summary

Predicted to enable D-glucose transmembrane transporter activity; alpha-glucoside transmembrane transporter activity; and glucose:sodium symporter activity. Predicted to be involved in several processes, including alpha-glucoside transport; import across plasma membrane; and renal potassium excretion. Predicted to act upstream of or within carbohydrate transport and ion transport. Predicted to be located in brush border membrane. Predicted to be active in plasma membrane. Predicted to be integral component of membrane. Is expressed in urinary system. Human ortholog(s) of this gene implicated in renal glycosuria. Orthologous to human SLC5A2 (solute carrier family 5 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc5a2 Products (1)

mRNA Protein Name
NM_133254.5 NP_573517.1 sodium/glucose cotransporter 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
11269503 MGI
Biological Process GO Annotation Evidence Verweise Source
involved in renal D-glucose absorption IMP
IMP: Inferred from mutant phenotype
20616166 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
20616166 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc5a2 Protein Structure

SLC5-6-like_sbd

SLC5-6-like_sbd: cl00456 (21 - 669)

  • 0
  • 200
  • 400
  • 600
  • 670 a.a.
Protein Preferred Names Protein Names

sodium/glucose cotransporter 2

  • Na(+)/glucose cotransporter 2

  • low affinity sodium-dependent glucose cotransporter

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS13286 SLC5A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13287 Slc5a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13288 Slc5a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc5a2 NCBI NCBI:6524