Laninamivir TFA
Based on 9 publication(s) in Google Scholar
Laninamivir TFA (R 125489 TFA) is an antiviral compound with inhibitory and prophylactic activity against influenza A and B viruses. Laninamivir TFA is a long-acting neuraminidase inhibitor administered by nasal inhalation. Laninamivir TFA has shown good safety and efficacy in the inhibition of influenza viruses.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 203120-18-7
- Formel: C15H23F3N4O9
- Molecular Weight:460.36
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) Laninamivir TFA
More- Nat Commun. 2025 Jul 1;16(1):5831. [Abstract]
- NPJ Digit Med. 2025 Nov 21;8(1):712. [Abstract]
- PLoS Pathog. 2026 Jan 23;22(1):e1013863. [Abstract]
- Sci Rep. 2021 Aug 11;11(1):16293. [Abstract]
- Int J Infect Dis. 2024 Sep:146:107134. [Abstract]
- Microbiol Spectr. 2026 Feb 18:e0332825. [Abstract]
- Viruses. 2024 Sep 14;16(9):1467. [Abstract]
- PLoS One. 2018 Jul 12;13(7):e0200761. [Abstract]
- Arch Virol. 2026 Jun 4;171(7):200.
Biologische Aktivität
Beschreibung
Chemical Information
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CAS. Nr. 203120-18-7
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Molecular Weight 460.36
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Formel C15H23F3N4O9
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SMILES
OC[C@@H](O)[C@H]([C@@]1([H])[C@@H]([C@H](C=C(C(O)=O)O1)NC(N)=N)NC(C)=O)OC.OC(C(F)(F)F)=O
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Synonyms
R 125489 TFA
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (9)
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Journal Impact Factor
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Most Recent
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Nat Commun
Single-domain antibodies directed against hemagglutinin and neuraminidase protect against influenza B viruses. [Abstract]2025 Jul 1;16(1):5831. PMID: 40593518 -
NPJ Digit Med
Predictive modeling & mechanistic validation of synergistic pimodivir combinations for anti-influenza therapy via PB2cap affinity boost. [Abstract]2025 Nov 21;8(1):712. PMID: 41272280 -
PLoS Pathog
Intra-patient neuraminidase mutations in avian H5N1 influenza virus reduce sialidase activity to complement weaker hemagglutinin binding and facilitate human infection. [Abstract]2026 Jan 23;22(1):e1013863. PMID: 41575943 -
Sci Rep
Substitution of I222L-E119V in neuraminidase from highly pathogenic avian influenza H7N9 virus exhibited synergistic resistance effect to oseltamivir in mice. [Abstract]2021 Aug 11;11(1):16293. PMID: 34381119 -
Int J Infect Dis
Antiviral susceptibility of SARS-CoV-2 and influenza viruses from 3 co-infected pediatric patients. [Abstract]2024 Sep:146:107134. PMID: 38944411 -
Microbiol Spectr
Neuraminidase of influenza A viruses induces global desialylation of host cells via its intracellular function. [Abstract]2026 Feb 18:e0332825. PMID: 41705853 -
Viruses
The Synergistic Effect of Baloxavir and Neuraminidase Inhibitors against Influenza Viruses In Vitro. [Abstract]2024 Sep 14;16(9):1467. PMID: 39339943 -
PLoS One
An easy, rapid, and sensitive method for detection of drug-resistant influenza virus by using a sialidase fluorescent imaging probe, BTP3-Neu5Ac. [Abstract]2018 Jul 12;13(7):e0200761. PMID: 30001430 -
Protokoll
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
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Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Laninamivir TFA Related Classifications
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