Metioprim
Metioprim is a competitive inhibitor of bacterial Dihydrofolate reductase (DHFR). Metioprim has inhibitory activity against anaerobic bacteria. Metioprim shows synergistic activity in combination with DDS (HY-B0688) against E. coli. and various mycobacteria.
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- CAS. Nr.: 68902-57-8
- Formel: C14H18N4O2S
- Molecular Weight:306.38
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Metioprim inhibits some anaerobic bacteria species with an average MIC value of 3.2 μg/mL[1].
Metioprim (0-1.0 μM; 0-8 h) suppresses bacterial growth kinetics, and inhibits E. coli with an MIC value of 0.7 μg/mL[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Pharmacokinetic Analysis[1]
| Animal | Route | Dose (mg/kg) | C0 (μg/mL) | A (μg/mL) | α (1/min) | t1/2α (min) | B (μg/mL) | β (1/min) | t1/2β (min) | VC (1/kg) | Vp (1/kg) | Vd,ss (1/kg) | Clβ (mL/min/kg) |
| Pigs | i.v. | 5 | 3.6 | 2.1 | 0.032 | 25 | 1.5 | 0.00415 | 169 | 1.45 | 0.74 | 2.19 | 10.0 |
| Goats | i.v. | 10 | 12.2 | 6.4 | 0.220 | 4 | 5.6 | 0.03138 | 23 | 0.85 | 0.44 | 1.28 | 49 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 68902-57-8
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Molecular Weight 306.38
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Formel C14H18N4O2S
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SMILES
NC1=NC(N)=C(CC2=CC(OC)=C(C(OC)=C2)SC)C=N1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Wüst J, et al. Activity of brodimoprim and metioprim alone and in combination with sulfonamides against anaerobic bacteria. Antimicrob Agents Chemother. 1983 Mar;23(3):490-2. [Content Brief]
[2]. Seydel JK, et al. Bacterial growth kinetics of Escherichia coli and mycobacteria in the presence of brodimoprim and metioprim alone and in combination with sulfamerazine and dapsone (VI). Chemotherapy. 1983;29(4):249-61. [Content Brief]
[3]. Nielsen P, et al. Pharmacokinetics and metabolism of metioprim in pigs and goats. Pharmacol Toxicol. 1987 Nov;61(5):330-4. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Metioprim Related Classifications
HY-122289 Related Classifications
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