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Art. -Nr.: HY-110015

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(-)-Chromanol 293B

(-)-Chromanol 293B is a potent and selective inhibitor of the slow component of delayed rectifier K⁺ current (IKs). (-)-Chromanol 293B can be used for the research of antiarrhythmic.

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CAS. Nr.: 163163-24-4
Formel: C₁₅H₂₀N₂O₄S
Molecular Weight:324.40

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

(-)-Chromanol 293B Chemical Structure

CAS. Nr.: 163163-24-4

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

(-)-Chromanol 293B is a potent and selective inhibitor of the slow component of delayed rectifier K⁺ current (IKs). (-)-Chromanol 293B can be used for the research of antiarrhythmic^[1].

IC₅₀ & Target

IKs^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
Oocyte	IC₅₀	5 μM Compound: (3R,4S)-enantiomer of 21	Inhibition of guinea pig Iks potassium channel expressed in Xenopus oocytes Inhibition of guinea pig Iks potassium channel expressed in Xenopus oocytes	[PMID: 14998318]
Oocyte	IC₅₀	5 μM Compound: 1a	Inhibition of human IKs-channel expressed in Xenopus oocytes,(Experiment 1) Inhibition of human IKs-channel expressed in Xenopus oocytes,(Experiment 1)	[PMID: 11689069]

In Vitro

(-)-Chromanol 293B selectively inhibits the KvLQT11＋minK ion channel complex^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 163163-24-4
Molecular Weight 324.40
Formel C₁₅H₂₀N₂O₄S
SMILES

CCS(=O)(N([C@@H]1[C@@H](O)C(C)(C)OC2=CC=C(C#N)C=C12)C)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Yang IC, et al. Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels. J Pharmacol Exp Ther. 2000;294(3):955-962. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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(-)-Chromanol 293B

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Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

(-)-Chromanol 293B Related Classifications

HY-110015 Related Classifications