Cyclaniliprole
Based on 1 Customer Validation
Cyclaniliprole is an insecticide and insect ryanodine receptor modulator with higher selectivity for insect ryanodine receptors than for mammalian ones. Cyclaniliprole exerts lethal effects on larvae and adults of various agricultural pests. Cyclaniliprole exhibits broad-spectrum insecticidal activity against pests of the orders Lepidoptera, Thysanoptera, Diptera, Hemiptera and Coleoptera.
For research use only. We do not sell to patients.
- Purity : 98.32%
- CAS No.: 1031756-98-5
- Formula: C21H17Br2Cl2N5O2
- Molecular Weight:602.11
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vivo
Cyclaniliprole exhibits high insecticidal activity against third-instar Spodoptera litura larvae, with an LC90 of 0.013 ppm[1].
Cyclaniliprole exhibits insecticidal activity against third-instar Helicoverpa armigera larvae, with an LC90 of 0.05 ppm[1].
Cyclaniliprole exhibits insecticidal activity against first-instar Frankliniella occidentalis larvae, with an LC90 of 22.7 ppm[1].
Cyclaniliprole exhibits insecticidal activity against newly hatched larvae of Thrips palmi, with an LC90 value of 5.6 ppm[1].
Cyclaniliprole exhibits insecticidal activity against newly hatched larvae of Thrips tabaci, with an LC90 of 18.5 ppm[1].
Cyclaniliprole exhibits insecticidal activity against adult Drosophila melanogaster, with an LC90 of 12.5 ppm[1].
Cyclaniliprole exhibits insecticidal activity against first-instar B-biotype Bemisia tabaci larvae, with an LC90 value of 3.1 ppm[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1031756-98-5
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Appearance Solid
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Molecular Weight 602.11
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Formula C21H17Br2Cl2N5O2
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Color White to off-white
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SMILES
O=C(NC(C)C1CC1)C=2C=C(Cl)C=C(Br)C2NC(=O)C3=CC(Br)=NN3C4=NC=CC=C4Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (83.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.08 mg/mL (3.45 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Protocols
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Calcium Spark Assay
Calcium sparks are localized, transient increases in intracellular calcium concentration ([Ca2+]i) that occur in cardiac myocytes and represent elementary events underlying excitation-contraction coupling. These events are generated by the coordinated opening of clusters of ryanodine receptors (RyRs) on the sarcoplasmic reticulum membrane, leading to a brief release of Ca2+ into the cytosol. The detection and analysis of calcium sparks provide insights into the mechanisms of calcium handling and signaling in cardiac cells. Imaging techniques using fluorescent calcium indicators such as Fluo-3 are employed to visualize these subcellular calcium transients with high spatial and temporal resolution. The protocol is based on established methodologies described in primary literature for both experimental measurement and automated analysis of calcium sparks.
Purity & Documentation
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Data Sheet (279 KB)
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SDS (458 KB)
- English - EN (458 KB)
- Français - FR (458 KB)
- Deutsch - DE (458 KB)
- Norwegian - NO (458 KB)
- Español - ES (458 KB)
- Swedish - SV (458 KB)
- Italian - IT (458 KB)
- Korean - KR (458 KB)
- Portuguese - PT (458 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.6608 mL | 8.3041 mL | 16.6083 mL | 41.5207 mL |
| 5 mM | 0.3322 mL | 1.6608 mL | 3.3217 mL | 8.3041 mL | |
| 10 mM | 0.1661 mL | 0.8304 mL | 1.6608 mL | 4.1521 mL | |
| 15 mM | 0.1107 mL | 0.5536 mL | 1.1072 mL | 2.7680 mL | |
| 20 mM | 0.0830 mL | 0.4152 mL | 0.8304 mL | 2.0760 mL | |
| 25 mM | 0.0664 mL | 0.3322 mL | 0.6643 mL | 1.6608 mL | |
| 30 mM | 0.0554 mL | 0.2768 mL | 0.5536 mL | 1.3840 mL | |
| 40 mM | 0.0415 mL | 0.2076 mL | 0.4152 mL | 1.0380 mL | |
| 50 mM | 0.0332 mL | 0.1661 mL | 0.3322 mL | 0.8304 mL | |
| 60 mM | 0.0277 mL | 0.1384 mL | 0.2768 mL | 0.6920 mL | |
| 80 mM | 0.0208 mL | 0.1038 mL | 0.2076 mL | 0.5190 mL |
Cyclaniliprole Related Classifications
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