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FLOT1 - flotillin 1 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10211

About FLOT1

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:30,727,709-30,742,687 (from NCBI)

This gene has 12 transcripts (splice variants), 1 gene allele, 279 orthologues and 1 paralogue. Ubiquitous expression in adrenal (RPKM 66.3), heart (RPKM 56.6) and 25 other tissues.

Summary

This gene encodes an protein that localizes to the caveolae, which are small domains on the inner cell membranes. This protein plays a role in vesicle trafficking and cell morphology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

FLOT1 Products (2)

mRNA	Protein	Name
NM_001318875.2	NP_001305804.1	flotillin-1 isoform 2
NM_005803.4	NP_005794.1	flotillin-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protease binding	IPI IPI: Inferred from physical interaction	24612608	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15469992	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to exogenous dsRNA	IMP IMP: Inferred from mutant phenotype	25204797	GOA
involved in dsRNA transport	IMP IMP: Inferred from mutant phenotype	25204797	GOA
involved in extracellular matrix disassembly	IMP IMP: Inferred from mutant phenotype	21119006	GOA
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	21399631	GOA
involved in plasma membrane raft assembly	IMP IMP: Inferred from mutant phenotype	21399631	GOA
acts upstream of positive effect plasma membrane raft organization	IMP IMP: Inferred from mutant phenotype	25204797	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	23319823	GOA
involved in positive regulation of cell junction assembly	IMP IMP: Inferred from mutant phenotype	24046456	GOA
involved in positive regulation of cell-cell adhesion mediated by cadherin	IMP IMP: Inferred from mutant phenotype	24046456	GOA
involved in positive regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	25204797	GOA
involved in positive regulation of endocytosis	IMP IMP: Inferred from mutant phenotype	21399631	GOA
involved in positive regulation of heterotypic cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	25204797	GOA
involved in positive regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	25204797	GOA
involved in positive regulation of myoblast fusion	IMP IMP: Inferred from mutant phenotype	24046456	GOA
involved in positive regulation of protein binding	IMP IMP: Inferred from mutant phenotype	24046456	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	25204797	GOA
involved in positive regulation of skeletal muscle tissue development	IMP IMP: Inferred from mutant phenotype	24046456	GOA
involved in positive regulation of toll-like receptor 3 signaling pathway	IMP IMP: Inferred from mutant phenotype	25204797	GOA
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	24046456	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	25204797	GOA
involved in regulation of neurotransmitter uptake	IDA IDA: Inferred from direct assay	21399631	GOA
involved in regulation of neurotransmitter uptake	IMP IMP: Inferred from mutant phenotype	21399631	GOA
involved in regulation of receptor internalization	IMP IMP: Inferred from mutant phenotype	21399631	GOA
NOT involved in regulation of toll-like receptor 4 signaling pathway	IMP IMP: Inferred from mutant phenotype	25204797	GOA
involved in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	25204797	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of COP9 signalosome	IDA IDA: Inferred from direct assay	18850735	GOA
located in adherens junction	IDA IDA: Inferred from direct assay	24046456	GOA
NOT located in apical plasma membrane	IDA IDA: Inferred from direct assay	23983584	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	23983584	GOA
located in cell-cell contact zone	IDA IDA: Inferred from direct assay	23983584	GOA
located in cell-cell junction	IDA IDA: Inferred from direct assay	25468996	GOA
located in centriolar satellite	IDA IDA: Inferred from direct assay	18000879	GOA
colocalizes with cortical actin cytoskeleton	IDA IDA: Inferred from direct assay	24046456	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	23983584	GOA
is active in dopaminergic synapse	IDA IDA: Inferred from direct assay	21399631	GOA
is active in dopaminergic synapse	IMP IMP: Inferred from mutant phenotype	21399631	GOA
located in early endosome	IDA IDA: Inferred from direct assay	21399631	GOA
located in endosome	IDA IDA: Inferred from direct assay	20682791	GOA
part of flotillin complex	IDA IDA: Inferred from direct assay	21399631	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	24046456	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	15469992	GOA
located in microtubule organizing center	IDA IDA: Inferred from direct assay	18000879	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21399631	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	21696602	GOA
located in uropod	IDA IDA: Inferred from direct assay	21696602	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FLOT1 Protein Structure

Band_7

0
100
200
300
400
427 a.a.

Protein Preferred Names	Protein Names
flotillin-1	integral membrane component of caveolae

FLOT1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FLOT1	O75955	CCDC102B	Homo sapiens	Q68D86	Validated Y2H	32296183
Intra	FLOT1	O75955	COX5B	Homo sapiens	P10606	Validated Y2H	32296183
Intra	FLOT1	O75955	BANP	Homo sapiens	Q8N9N5-2	Validated Y2H	32296183
Intra	FLOT1	O75955	FLOT2	Homo sapiens	Q14254	PLA	24167781
Intra	FLOT1	O75955	FLOT2	Homo sapiens	Q14254	IF	24809731
Intra	FLOT1	O75955	EMP3	Homo sapiens	P54852	PLA	30614533
Intra	FLOT1	O75955	EMP3	Homo sapiens	P54852	BiFC	30614533
Intra	FLOT1	O75955	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	FLOT1	O75955	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	FLOT1	O75955	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	FLOT1	O75955	FAM90A1	Homo sapiens	Q86YD7	Validated Y2H	32296183
Intra	FLOT1	O75955	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	32296183
Intra	FLOT1	O75955	APP	Homo sapiens	P05067	Anti Bait CoIP	16480949
Intra	FLOT1	O75955	APP	Homo sapiens	P05067	Y2H	16480949

Cross: Cross-species interaction Intra: Intraspecies interaction

FLOT1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80675	Flotillin-1 Antibody (YA760)	WB	Mouse, Rat
HY-P80675A	Flotillin-1 Antibody (YA760)(PBS only)	WB	Mouse, Rat
HY-P84936	Flotillin-1 Antibody (YA4632)	WB, ICC/IF, IP	Human
HY-P84936A	Flotillin-1 Antibody (YA4632)(PBS only)	WB, ICC/IF, IP	Human
HY-P84937	Flotillin-1 Antibody (YA4633)	WB, IHC-P	Human, Mouse, Rat
HY-P86222	Flotillin-1 Antibody (YA5914)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Mycobacterium Marinum	Mycobacterium Marinum Infection Fish Tank Granuloma M. Marinum
Open-Angle Glaucoma	Glaucoma Simplex Pigmentary Glaucoma Wide-Angle Glaucoma Glaucoma, Open-Angle Open Angle Glaucoma Glaucoma Open-Angle Chronic Simple Glaucoma Coag - [Chronic Open-Angle Glaucoma] Csg - [Chronic Simple Glaucoma] Poag - [Primary Open-Angle Glaucoma] Oag - [Open-Angle Glaucoma] Chronic Glaucoma Chronic Open Angle Glaucoma Simple Glaucoma Chronic Noncongestive Glaucoma Ltg - [Low Tension Glaucoma] Noncongestive Glaucoma Nonobstructive Glaucoma Normal Pressure Glaucoma Primary Low Tension Glaucoma Low-Tension Glaucoma Residual Stage Low Tension Glaucoma Open Cleft Glaucoma
Cortical Dysplasia, Complex, With Other Brain Malformations 6	Complex Cortical Dysplasia With Other Brain Malformations 6 CDCBM6 Cdcbm56 Dysplasia ,Cortical, Complex, With Other Brain Malformations, Type 6
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Bardet-Biedl Syndrome	Bbs Biedl-Bardet Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04982	FLOT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FLOT1	RGD	RGD:70991
Felis catus	FLOT1	VGNC	VGNC:62294
Macaca mulatta	FLOT1	VGNC	VGNC:72674
Bos taurus	FLOT1	VGNC	VGNC:29036
Canis familiaris	FLOT1	VGNC	VGNC:40903
Mus musculus	FLOT1	MGD	MGI:1100500
Others	FLOT1	NCBI