ROR1 - receptor tyrosine kinase like orphan receptor 1 Gene

Also Known as NTRKR1; dJ537F10.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4919

About ROR1

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:63,774,017-64,181,498 (from NCBI)

This gene has 3 transcripts (splice variants), 209 orthologues, 53 paralogues and is associated with 2 phenotypes. Ubiquitous expression in lung (RPKM 2.7), endometrium (RPKM 2.2) and 23 other tissues.

Summary

This gene encodes a receptor tyrosine kinase-like Orphan Receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]

ROR1 Products (2)

mRNA	Protein	Name
NM_001083592.2	NP_001077061.1	inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform 2 precursor
NM_005012.4	NP_005003.2	inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Wnt receptor activity	IMP IMP: Inferred from mutant phenotype	27162350	GOA
enables Wnt-protein binding	IPI IPI: Inferred from physical interaction	18287027	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22439932	GOA
enables signaling receptor activity	IDA IDA: Inferred from direct assay	36949068	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell population proliferation	IDA IDA: Inferred from direct assay	36949068	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	27162350	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	27162350	GOA
involved in sensory perception of sound	IMP IMP: Inferred from mutant phenotype	27162350	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	27162350	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ROR1 Protein Structure

I-set

Kringle

Pkinase_Tyr

0
200
400
600
800
937 a.a.

Protein Preferred Names	Protein Names
inactive tyrosine-protein kinase transmembrane receptor ROR1	neurotrophic tyrosine kinase, receptor-related 1

ROR1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ROR1	Q01973	EGFR	Homo sapiens	P00533	Anti Bait CoIP	22439932
Intra	ROR1	Q01973	EGFR	Homo sapiens	P00533	Anti Tag CoIP	22439932
Cross	ROR1	Q01973	Src	Mus musculus	P05480	Anti Bait CoIP	22439932
Intra	ROR1	Q01973	SRC	Homo sapiens	P12931	Pull Down	22439932
Intra	ROR1	Q01973	SRC	Homo sapiens	P12931	Anti Bait CoIP	22439932
Intra	ROR1	Q01973	SRC	Homo sapiens	P12931	Protein Kinase Assay	22439932
Intra	ROR1	Q01973	SRC	Homo sapiens	P12931	Anti Tag CoIP	22439932

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ROR1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70732	ROR1 Protein, Human (HEK293, His)	Q01973-1 (Q30-E403)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72410	ROR1 Protein, Human (Biotinylated, HEK293, His-Avi)	Q01973-1 (Q30-E403)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73390	ROR1 Protein, Human (sf9, His)	Q01973-1 (M453-N783)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78510	ROR1 Protein, Human (HEK293, His-Avi)	Q01973-1 (Q30-E403)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78815	ROR1 Protein, Human (Biotinylated, HEK293, Fc-Avi)	Q01973-1 (Q30-E403)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78816	ROR1 Protein, Human (Biotinylated, HEK293, Avi)	Q01973-1 (Q30-E403)	≥ 95%, as determined by reducing SDS-PAGE.

ROR1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81741	ROR1 Antibody (YA1486)	FC, ELISA	Human
HY-P84465	ROR1 Antibody (YA4162)	WB, ICC/IF, ELISA	Human
HY-P84465A	ROR1 Antibody (YA4162)(PBS only)	WB, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Deafness, Autosomal Recessive 108	DFNB108 Deafness, Autosomal Recessive, 108
Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb	Autosomal Recessive Isolated Neurosensory Deafness Type Dfnb Autosomal Recessive Isolated Neurosensory Hearing Loss Type Dfnb Autosomal Recessive Isolated Sensorineural Deafness Type Dfnb Autosomal Recessive Isolated Sensorineural Hearing Loss Type Dfnb Autosomal Recessive Non-Syndromic Neurosensory Deafness Type Dfnb Autosomal Recessive Non-Syndromic Neurosensory Hearing Loss Type Dfnb Autosomal Recessive Non-Syndromic Sensorineural Hearing Loss Type Dfnb
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Robinow Syndrome	Acral Dysostosis With Facial And Genital Abnormalities Fetal Face Syndrome Robinow Dwarfism Mesomelic Dwarfism-Small Genitalia Syndrome Robinow-Silverman-Smith Syndrome Costovertebral Segmentation Defect With Mesomelia Covesdem Syndrome Robinow'S Syndrome Robinow-Silverman Syndrome
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99201	Zilovertamab	Inhibitor	98.21%	Phase 3
HY-P99956	Zilovertamab vedotin	Inducer	99.77%	Phase 3
HY-P991209	Nebratamig	Inhibitor	97.34%	Phase 2
HY-P99828	Cofetuzumab		99.31%	Phase 1

Pre-clinical Phase

Bioactive Molecules (24)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139534	ARI-1		99.16%	Unkown
HY-126686	Mal-Phe-C4-VC-PAB-MMAE		99.54%	Unkown
HY-162640	LDR102	Inhibitor	99.78%	Unkown
HY-135319	Strictinin		97.15%	Unkown
HY-139534A	(S)-ARI-1	Control	99.80%	Unkown
HY-160806	(5-Cl)-Exatecan	Inhibitor	/	Unkown
HY-161096	Antitumor agent-127		99.09%	Unkown
HY-160806A	(5-Cl)-Exatecan TFA	Inhibitor	/	Unkown
HY-117947	(R)-OR-S1	Control	/	Unkown
HY-170995	PROTAC ROR1 degrader-1		/	Unkown
HY-170996	ROR1 ligand-1	Degrader	/	Unkown
HY-174382	ROR1-IN-3		/	Unkown
HY-175497	ROR1-IN-4		/	Unkown
HY-176190	ROR1-IN-2	Inhibitor	/	Unkown
HY-177109	BL20-MMAE	Inhibitor	/	Unkown
HY-183031	BrAA-glycine-BG-PAB-Exatecan		/	Unkown
HY-P11858	DP1 peptide	Ligand	/	Unkown
HY-P11859	NP1	Ligand	/	Unkown
HY-RS12124	ROR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12126	RORA Human Pre-designed siRNA Set A		/	Unkown
HY-RS12127	Rora Mouse Pre-designed siRNA Set A		/	Unkown
HY-160790	β-Glu-PNP		/	Unkown
HY-RS16801	Ror1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23242	Ror1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992337	CS5001 Antibody	Inhibitor	/	Unkown
HY-P992376	huXBR1-402	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ROR1	RGD	RGD:1559469
Bos taurus	ROR1	VGNC	VGNC:55673
Canis familiaris	ROR1	VGNC	VGNC:45693
Mus musculus	ROR1	MGD	MGI:1347520
Macaca mulatta	ROR1	VGNC	VGNC:76715
Felis catus	ROR1	VGNC	VGNC:64719
Others	ROR1	NCBI