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SH3GL2 - SH3 domain containing GRB2 like 2, endophilin A1 Gene

Also Known as CNSA2; SH3P4; EEN-B1; SH3D2A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6456

About SH3GL2

Cytogenetic location: 9p22.2 Genomic coordinates (GRCh38): 9:17,579,066-17,797,124 (from NCBI)

This gene has 2 transcripts (splice variants), 182 orthologues and 12 paralogues. Biased expression in brain (RPKM 24.2), kidney (RPKM 2.6) and 1 other tissue.

Summary

Enables identical protein binding activity. Involved in negative regulation of blood-brain barrier permeability; negative regulation of gene expression; and negative regulation of protein phosphorylation. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SH3GL2 Products (1)

mRNA	Protein	Name
NM_003026.5	NP_003017.1	endophilin-A1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16115810	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10531379	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of blood-brain barrier permeability	IMP IMP: Inferred from mutant phenotype	24854121	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24854121	GOA
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	24854121	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in perinuclear region of cytoplasm	IMP IMP: Inferred from mutant phenotype	24854121	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
endophilin-A1	Endophilin A1 BAR domain

SH3GL2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SH3GL2	Q99962	DNM2	Homo sapiens	P50570	SPR	16696976
Intra	SH3GL2	Q99962	DNM2	Homo sapiens	P50570	SPR	15834155
Intra	SH3GL2	Q99962	SH3KBP1	Homo sapiens	Q96B97	Pull Down	11894096
Intra	SH3GL2	Q99962	SH3KBP1	Homo sapiens	Q96B97	Y2H	21900206
Intra	SH3GL2	Q99962	RAPH1	Homo sapiens	Q70E73	Pull Down	25517094
Intra	SH3GL2	Q99962	RAPH1	Homo sapiens	Q70E73	Pull Down	24076656
Intra	SH3GL2	Q99962	SH3GL3	Homo sapiens	Q99963	Anti Tag CoIP	16115810
Intra	SH3GL2	Q99962	SH3GL3	Homo sapiens	Q99963	Anti Tag CoIP	33961781
Intra	SH3GL2	Q99962	SH3GL3	Homo sapiens	Q99963	Y2H	21900206
Intra	SH3GL2	Q99962	SH3GL3	Homo sapiens	Q99963	Y2H	16115810
Intra	SH3GL2	Q99962	LRRK2	Homo sapiens	Q5S007	Protein Kinase Assay	22998870
Intra	SH3GL2	Q99962	LRRK2	Homo sapiens	Q5S007	Protein Kinase Assay	25501810
Intra	SH3GL2	Q99962	ATXN2	Homo sapiens	Q99700	Anti Tag CoIP	18602463
Intra	SH3GL2	Q99962	ATXN2	Homo sapiens	Q99700	Pull Down	18602463
Intra	SH3GL2	Q99962	ATXN2	Homo sapiens	Q99700	Anti Tag CoIP	16115810
Intra	SH3GL2	Q99962	ATXN2	Homo sapiens	Q99700	Y2H	18602463
Intra	SH3GL2	Q99962	SH3GL1	Homo sapiens	Q99961	Anti Tag CoIP	33961781
Intra	SH3GL2	Q99962	SH3GL1	Homo sapiens	Q99961	Anti Tag CoIP	28514442
Intra	SH3GL2	Q99962	PTPN23	Homo sapiens	Q9H3S7	Y2H	17174262
Intra	SH3GL2	Q99962	ADAM15	Homo sapiens	Q13444	Pull Down	10531379
Intra	SH3GL2	Q99962	ADAM15	Homo sapiens	Q13444	Y2H	10531379
Intra	SH3GL2	Q99962	ADAM9	Homo sapiens	Q13443	Y2H	10531379
Intra	SH3GL2	Q99962	ADAM9	Homo sapiens	Q13443	Pull Down	10531379
Intra	SH3GL2	Q99962	SH3GL2	Homo sapiens	Q99962	Anti Tag CoIP	25517094
Intra	SH3GL2	Q99962	SH3GL2	Homo sapiens	Q99962	Pull Down	20404169
Intra	SH3GL2	Q99962	SH3GL2	Homo sapiens	Q99962	Anti Tag CoIP	16115810
Intra	SH3GL2	Q99962	SH3GL2	Homo sapiens	Q99962	Y2H	16115810
Cross	SH3GL2	Q99962	Synj1	Rattus norvegicus	Q62910	Y2H	10764144

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Childhood Pilocytic Astrocytoma	Pediatric Pilocytic Astrocytoma
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12837	SH3GL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SH3GL2	VGNC	VGNC:77204
Rattus norvegicus	SH3GL2	RGD	RGD:620276
Mus musculus	SH3GL2	MGD	MGI:700009
Canis familiaris	SH3GL2	VGNC	VGNC:46125
Bos taurus	SH3GL2	VGNC	VGNC:34573
Felis catus	SH3GL2	VGNC	VGNC:65107
Others	SH3GL2	NCBI