Synj1 - synaptojanin 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 85238

Summary

Enables Phosphatase activity; protein C-terminus binding activity; and protein domain specific binding activity. Involved in several processes, including nervous system development; positive regulation of receptor-mediated endocytosis; and response to retinoic acid. Located in cytoplasm; neuron projection; and synaptic membrane. Part of clathrin coat of coated pit. Is active in parallel fiber to Purkinje cell synapse and presynapse. Colocalizes with microtubule. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 20; and developmental and epileptic encephalopathy 53. Orthologous to human SYNJ1 (synaptojanin 1). [provided by Alliance of Genome Resources, Apr 2022]

Synj1 Products (1)

mRNA	Protein	Name
NM_053476.3	NP_445928.2	synaptojanin-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables EH domain binding	IDA IDA: Inferred from direct assay	9428629	RGD
enables SH3 domain binding	IDA IDA: Inferred from direct assay	8552192	RGD
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	11498538	RGD
enables inositol-1,4,5-trisphosphate 5-phosphatase activity	IDA IDA: Inferred from direct assay	8552192	RGD
enables phosphatidylinositol phosphate 5-phosphatase activity	IDA IDA: Inferred from direct assay	8552192	RGD
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IDA IDA: Inferred from direct assay	8552192	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9238017	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	17257598	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of gliogenesis	IMP IMP: Inferred from mutant phenotype	19282871	RGD
involved in positive regulation of receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	15821731	RGD
involved in response to cytokine	IMP IMP: Inferred from mutant phenotype	19282871	RGD
involved in response to retinoic acid	IMP IMP: Inferred from mutant phenotype	19282871	RGD

Cellular Component GO Annotation	Evidence	References	Source
part of clathrin coat of coated pit	IDA IDA: Inferred from direct assay	9428629	RGD
located in membrane	IDA IDA: Inferred from direct assay	8798761	RGD
located in microtubule	IDA IDA: Inferred from direct assay	9428629	RGD
is active in parallel fiber to Purkinje cell synapse	IDA IDA: Inferred from direct assay	7982917	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	7982917	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	17257598	RGD
located in synaptic membrane	IDA IDA: Inferred from direct assay	9079704	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
synaptojanin-1	synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1

Synj1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Synj1	Q62910	MYO1E	Homo sapiens	Q12965	Pull Down	17257598
Cross	Synj1	Q62910	SH3GL2	Homo sapiens	Q99962	Pull Down	17257598

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14093	SYNJ1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Synj1	NCBI	NCBI:8867