DHFR-IN-11
DHFR-IN-11 (compound 6b) is inhibitor of DHFR, and has inhibitory potency versus M. tuberculosis DHFR enzyme with IC50 values 5.70 μM.
For research use only. We do not sell to patients.
- Formula: C18H17N3O3S2
- Molecular Weight:387.48
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
IC50 & Target
5.70 μM versus M. tuberculosis DHFR enzyme[1].
Chemical Information
-
Molecular Weight 387.48
-
Formula C18H17N3O3S2
-
SMILES
O=C1N=C(N2N=C(C3=CC=CS3)CC2C4=CC(OC)=CC=C4OC)SC1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Dawood DH, et, al. New Thiophenyl-pyrazolyl-thiazole Hybrids as DHFR Inhibitors: Design, Synthesis, Antimicrobial Evaluation, Molecular Modeling, and Biodistribution Studies. ACS Omega. 2023 Oct 13;8(42):39250-39268. [Content Brief]
[2]. Dawood DH, et al. New Thiophenyl-pyrazolyl-thiazole Hybrids as DHFR Inhibitors: Design, Synthesis, Antimicrobial Evaluation, Molecular Modeling, and Biodistribution Studies. ACS Omega. 2023;8(42):39250-39268. Published 2023 Oct 13. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DHFR-IN-11 Related Classifications
HY-156414 Related Classifications
Powered by Bioz