2. Metabolic Enzyme/Protease
  3. Dihydrofolate reductase (DHFR)
  4. DHFR-IN-12

DHFR-IN-12 (Compound 5c) is a DHFR inhibitor which has good antibacterial activity.

For research use only. We do not sell to patients.

DHFR-IN-12 Chemical Structure

DHFR-IN-12 Chemical Structure

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DHFR-IN-12 Related Antibodies

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Description

DHFR-IN-12 (Compound 5c) is a DHFR inhibitor which has good antibacterial activity[1].

In Vitro

DHFR-IN-12 (Compound 5c, 521 μM) with excellent antibacterial activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DHFR-IN-12 Related Antibodies
In Vivo

DHFR-IN-12 (5% w/v; 3 days) can significantly reduce keratitis infection in rats. Compared with MRSA group, the % of corneal opacity IN DHFRin-12 treated group was significantly reduced [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague–Dawley rats (200 ± 15 g)[1]
Dosage: (5% w/v; 3 days)
Administration: Dripping on the cornea
Result: Reduced keratitis infection in rats.
Compared with MRSA group, the % of corneal opacity was significantly reduced.
Molecular Weight

479.53

Formula

C28H25N5O3
SMILES

N=C1N=C(C2=CC(OC)=C(OC)C(OC)=C2)C=C(C3=CN(C4=CC=CC=C4)N=C3C5=CC=CC=C5)N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DHFR-IN-12 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DHFR-IN-12Dihydrofolate reductase (DHFR)DHFRAntimicrobial Inhibitorinhibitorinhibit

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DHFR-IN-12
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HY-149699
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