country

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-149699

Copy Link Print Information

DHFR-IN-12

DHFR-IN-12 (Compound 5c) is a DHFR inhibitor which has good antibacterial activity.

For research use only. We do not sell to patients.

Formula: C₂₈H₂₅N₅O₃
Molecular Weight:479.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

DHFR-IN-12 Chemical Structure

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

DHFR-IN-12 (Compound 5c) is a DHFR inhibitor which has good antibacterial activity^[1].

In Vitro

DHFR-IN-12 (Compound 5c, 521 μM) with excellent antibacterial activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DHFR-IN-12 (5% w/v; 3 days) can significantly reduce keratitis infection in rats. Compared with MRSA group, the % of corneal opacity IN DHFRin-12 treated group was significantly reduced ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Adult male Sprague–Dawley rats (200 ± 15 g)^[1]
Dosage:

(5% w/v; 3 days)
Administration:

Dripping on the cornea
Result:

Reduced keratitis infection in rats.
Compared with MRSA group, the % of corneal opacity was significantly reduced.

Chemical Information

Molecular Weight 479.53
Formula C₂₈H₂₅N₅O₃
SMILES

N=C1N=C(C2=CC(OC)=C(OC)C(OC)=C2)C=C(C3=CN(C4=CC=CC=C4)N=C3C5=CC=CC=C5)N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mansour B, et al. New Pyrazole-Clubbed Pyrimidine or Pyrazoline Hybrids as Anti-Methicillin-Resistant Staphylococcus aureus Agents: Design, Synthesis, In Vitro and In Vivo Evaluation, and Molecular Modeling Simulation[J]. ACS Omega, 2023.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

Get Quote In-stock