2. Others Immunology/Inflammation Apoptosis
  3. Environmental Pollutants MDM-2/p53 Aryl Hydrocarbon Receptor
  4. Dibenzo(a,i)pyrene

Dibenzo (a,i) pyrene is a polycyclic aromatic hydrocarbon and also a carcinogenic ligand of the TCDD (Ah) receptor. Dibenzo (a,i) pyrene binds to the TCDD (Ah) receptor in rat liver. Dibenzo (a,i) pyrene induces DNA adduct formation and upregulates the protein levels of p53 and p21WAF1 in diploid lung fibroblasts. Dibenzo (a,i) pyrene alters the cell cycle distribution of diploid lung fibroblasts, increasing the proportion of cells in the S phase, decreasing the proportions of cells in the G0/G1 and G2/M phases, and causing S phase delay/arrest. Dibenzo (a,i) pyrene is applicable for cancer research.

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Dibenzo(a,i)pyrene

Dibenzo(a,i)pyrene Chemical Structure

CAS No. : 189-55-9

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Dibenzo(a,i)pyrene Related Antibodies

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Description

Dibenzo (a,i) pyrene is a polycyclic aromatic hydrocarbon and also a carcinogenic ligand of the TCDD (Ah) receptor. Dibenzo (a,i) pyrene binds to the TCDD (Ah) receptor in rat liver. Dibenzo (a,i) pyrene induces DNA adduct formation and upregulates the protein levels of p53 and p21WAF1 in diploid lung fibroblasts. Dibenzo (a,i) pyrene alters the cell cycle distribution of diploid lung fibroblasts, increasing the proportion of cells in the S phase, decreasing the proportions of cells in the G0/G1 and G2/M phases, and causing S phase delay/arrest. Dibenzo (a,i) pyrene is applicable for cancer research[1][2].

In Vitro

Dibenzo(a,i)pyrene binds to rat liver TCDD receptors with a log IC50 of 1.00[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dibenzo(a,i)pyrene Related Antibodies
Molecular Weight

302.37

Formula

C24H14
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

C12=CC3=CC=C4C(C5=C6C(C=CC=C6)=C4)=C3C(C=C5)=C1C=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : < 1 mg/mL (insoluble or slightly soluble)

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Purity & Documentation

Purity: 98.0%

SDS (700 KB)

COA (253 KB) HNMR (255 KB)

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Dibenzo(a,i)pyrene Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dibenzo(a,i)pyrene189-55-9Environmental PollutantsMDM-2/p53Aryl Hydrocarbon ReceptorEnvironmental ContaminantsAhRcarcinogenic ligand of the TCDD (Ah) receptoTCDD (Ah) receptorcancerdiploid lung fibroblastsInhibitorinhibitorinhibit

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