189-55-9
Chemical Structure
Dibenzo(a,i)pyrene
- CAS No.: 189-55-9
- Formula:C24H14
- Molecular Weight:302.37
IUPAC Name: benzo[rst]pentaphene
InChIKey: TUGYIJVAYAHHHM-UHFFFAOYSA-N
SMILES: C12=CC3=CC=C4C(C5=C6C(C=CC=C6)=C4)=C3C(C=C5)=C1C=CC=C2
Biological Activity: Dibenzo (a,i) pyrene is a polycyclic aromatic hydrocarbon and also a carcinogenic ligand of the TCDD (Ah) receptor. Dibenzo (a,i) pyrene binds to the TCDD (Ah) receptor in rat liver. Dibenzo (a,i) pyrene induces DNA adduct formation and upregulates the protein levels of p53 and p21WAF1 in diploid lung fibroblasts. Dibenzo (a,i) pyrene alters the cell cycle distribution of diploid lung fibroblasts, increasing the proportion of cells in the S phase, decreasing the proportions of cells in the G0/G1 and G2/M phases, and causing S phase delay/arrest. Dibenzo (a,i) pyrene is applicable for cancer research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Dibenzo(a,i)pyrene | 98.0% | Dibenzo (a,i) pyrene is a polycyclic aromatic hydrocarbon and also a carcinogenic ligand of the TCDD (Ah) receptor. Dibenzo (a,i) pyrene binds to the TCDD (Ah) receptor in rat liver. Dibenzo (a,i) pyrene induces DNA adduct formation and upregulates the protein levels of p53 and p21WAF1 in diploid lung fibroblasts. Dibenzo (a,i) pyrene alters the cell cycle distribution of diploid lung fibroblasts, increasing the proportion of cells in the S phase, decreasing the proportions of cells in the G0/G1 and G2/M phases, and causing S phase delay/arrest. Dibenzo (a,i) pyrene is applicable for cancer research. | ||||||||||||||||||||
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Dibenzo(a,i)pyrene-d14 | Dibenzo(a,i)pyrene-d14 is the deuterium labeled Dibenzo(a,i)pyrene. | |||||||||||||||||||||
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- [1]. Johnels, D., ey al. Quantitative Structure-Activity Relationship (QSAR) Analysis Using the Partial Least Squares (PLS) Method: The Binding of Polycyclic Aromatic Hydrocarbons (PAH) to the Rat Liver 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD) Receptor. Quant. Struct.-Act. Relat., 8: 83-89.
- [2]. Binková B, ey al. The effect of dibenzo[a,1]pyrene and benzo[a]pyrene on human diploid lung fibroblasts: the induction of DNA adducts, expression of p53 and p21(WAF1) proteins and cell cycle distribution. Mutat Res. 2000 Nov 20;471(1-2):57-70. [Content Brief]
