MED16 - mediator complex subunit 16 Gene

Also Known as DRIP92; THRAP5; TRAP95

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10025

About MED16

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:867,963-893,187 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele and 200 orthologues. Ubiquitous expression in ovary (RPKM 10.5), kidney (RPKM 10.1) and 25 other tissues.

Summary

Enables Thyroid Hormone Receptor binding activity and transcription coactivator activity. Involved in positive regulation of transcription initiation from RNA polymerase II promoter. Located in membrane. Part of mediator complex. [provided by Alliance of Genome Resources, Apr 2022]

MED16 Products (1)

mRNA Protein Name
NM_005481.3 NP_005472.2 mediator of RNA polymerase II transcription subunit 16

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nuclear thyroid hormone receptor binding IDA
IDA: Inferred from direct assay
10198638 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24882805 GOA
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
10198638 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10198638 GOA
involved in positive regulation of transcription initiation by RNA polymerase II IDA
IDA: Inferred from direct assay
12218053 GOA
Cellular Component GO Annotation Evidence References Source
part of core mediator complex IPI
IPI: Inferred from physical interaction
24882805 GOA
part of mediator complex IDA
IDA: Inferred from direct assay
10198638 GOA
located in nucleus IDA
IDA: Inferred from direct assay
24882805 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED16 Protein Structure

WD40

WD40: WD domain, G-beta repeat (77 - 109)

Med16

Med16: Mediator complex subunit 16 (126 - 828)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 877 a.a.
Protein Preferred Names Protein Names

mediator of RNA polymerase II transcription subunit 16

  • thyroid hormone receptor-associated protein 5

MED16 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MED16 Q9Y2X0 MED23 Homo sapiens Q9ULK4
Anti Tag CoIP
24882805
Intra
MED16 Q9Y2X0 MED14 Homo sapiens O60244
Anti Tag CoIP
24882805
Intra
MED16 Q9Y2X0 MED24 Homo sapiens O75448
Anti Tag CoIP
24882805
Intra
MED16 Q9Y2X0 MED25 Homo sapiens Q71SY5
Anti Tag CoIP
24882805
Cross: Cross-species interaction Intra: Intraspecies interaction

MED16 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89946 TRAP95 Antibody (YA9290) WB, ICC/IF, IF-Tissue, IP human

Related Diseases

Diseases Alias
Mixed Fibrolamellar Hepatocellular Carcinoma
Lipodystrophy, Congenital Generalized, Type 3

  • Congenital Generalized Lipodystrophy Type 3

  • CGL3

  • Bscl3

  • Berardinelli-Seip Congenital Lipodystrophy Type 3

  • Berardinelli-Seip Congenital Lipodystrophy, Type 3

  • Lipodystrophy, Berardinelli-Seip Congenital, Type 3

  • Type 3 Berardinelli-Seip Congenital Lipodystrophy

  • Congenital Generalized Lipodystrophy 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08287 MED16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MED16 VGNC VGNC:31354
Canis familiaris MED16 VGNC VGNC:43126
Mus musculus MED16 MGD MGI:2158394
Felis catus MED16 VGNC VGNC:80624
Rattus norvegicus MED16 RGD RGD:1308001
Macaca mulatta MED16 VGNC VGNC:74525
Others MED16 NCBI