Alad - aminolevulinate dehydratase Gene

Also Known as ALADR; aminolevulinatedelta-dehydratase

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25374

Summary

Enables porphobilinogen synthase activity and Proteasome core complex binding activity. Involved in several processes, including cellular response to lead ion; response to herbicide; and response to vitamin. Located in cytosol and extracellular space. Used to study anemia and hemochromatosis. Biomarker of acute kidney failure; hypothyroidism; liver cirrhosis; status epilepticus; and visual epilepsy. Human ortholog(s) of this gene implicated in porphyria cutanea tarda and sickle cell anemia. Orthologous to human ALAD (aminolevulinate dehydratase). [provided by Alliance of Genome Resources, Apr 2022]

Alad Products (1)

mRNA Protein Name
NM_012899.2 NP_037031.1 delta-aminolevulinic acid dehydratase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables porphobilinogen synthase activity IDA
IDA: Inferred from direct assay
19095280 RGD
enables proteasome core complex binding IDA
IDA: Inferred from direct assay
21640720 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to lead ion IEP
IEP: Inferred from expression pattern
16566714 RGD
involved in heme biosynthetic process IDA
IDA: Inferred from direct assay
1764448 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
12171438 RGD
involved in response to aluminum ion IEP
IEP: Inferred from expression pattern
518129 RGD
involved in response to amino acid IEP
IEP: Inferred from expression pattern
8295845 RGD
involved in response to arsenic-containing substance IDA
IDA: Inferred from direct assay
17086449 RGD
involved in response to arsenic-containing substance IEP
IEP: Inferred from expression pattern
19966145 RGD
involved in response to cadmium ion IDA
IDA: Inferred from direct assay
7896311 RGD
involved in response to cadmium ion IEP
IEP: Inferred from expression pattern
20019094 RGD
involved in response to cobalt ion IEP
IEP: Inferred from expression pattern
826600 RGD
involved in response to ethanol IDA
IDA: Inferred from direct assay
2394940 RGD
involved in response to fatty acid IEP
IEP: Inferred from expression pattern
20026167 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
12596873 RGD
involved in response to herbicide IEP
IEP: Inferred from expression pattern
12180188 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
9468112 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
3697363 RGD
involved in response to ionizing radiation IEP
IEP: Inferred from expression pattern
17916974 RGD
involved in response to iron ion IEP
IEP: Inferred from expression pattern
14598909 RGD
involved in response to lead ion IEP
IEP: Inferred from expression pattern
16597373 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
19344711 RGD
involved in response to mercury ion IEP
IEP: Inferred from expression pattern
17881112 RGD
involved in response to metal ion IDA
IDA: Inferred from direct assay
15302091 RGD
involved in response to metal ion IEP
IEP: Inferred from expression pattern
3629603 RGD
involved in response to methylmercury IEP
IEP: Inferred from expression pattern
19874286 RGD
involved in response to nutrient IDA
IDA: Inferred from direct assay
2394940 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
8000239 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
19647414 RGD
involved in response to oxidative stress IEP
IEP: Inferred from expression pattern
17916976 RGD
involved in response to platinum ion IEP
IEP: Inferred from expression pattern
925603 RGD
involved in response to selenium ion IEP
IEP: Inferred from expression pattern
15721883 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
20517888 RGD
involved in response to vitamin IEP
IEP: Inferred from expression pattern
9559098 RGD
involved in response to vitamin B1 IEP
IEP: Inferred from expression pattern
20088549 RGD
involved in response to vitamin E IEP
IEP: Inferred from expression pattern
17572058 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
8070841 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
19486337 RGD
involved in response to zinc ion IDA
IDA: Inferred from direct assay
3987589 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
19111884 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

delta-aminolevulinic acid dehydratase

  • ALADH

  • aminolevulinate, delta-, dehydratase

  • delta - aminolevulinic acid dehydratase

  • porphobilinogen synthase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00553 ALAD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17104 Alad Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23548 Alad Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Alad NCBI NCBI:210