DYNLRB1 - dynein light chain roadblock-type 1 Gene

Also Known as BLP; BITH; DNCL2A; DNLC2A; ROBLD1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83658

About DYNLRB1

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:34,515,602-34,540,958 (from NCBI)

This gene has 5 transcripts (splice variants), 162 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 34.0), kidney (RPKM 31.8) and 25 other tissues.

Summary

This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013]

DYNLRB1 Products (5)

mRNA Protein Name
NM_001319157.2 NP_001306086.1 dynein light chain roadblock-type 1 isoform d
NM_001382365.1 NP_001369294.1 dynein light chain roadblock-type 1 isoform a
NM_001382366.1 NP_001369295.1 dynein light chain roadblock-type 1 isoform e
NM_001382367.1 NP_001369296.1 dynein light chain roadblock-type 1 isoform f
NM_014183.4 NP_054902.1 dynein light chain roadblock-type 1 isoform a

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
part of dynein complex IPI
IPI: Inferred from physical interaction
24986880 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DYNLRB1 Protein Structure

Robl_LC7

Robl_LC7: Roadblock/LC7 domain (4 - 93)

  • 0
  • 96 a.a.
Protein Preferred Names Protein Names

dynein light chain roadblock-type 1

  • ROBL/LC7-like 1

DYNLRB1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DYNLRB1 Q9NP97 MAGEA2 Homo sapiens P43356
Y2H Prey Pooling
32296183
Intra
DYNLRB1 Q9NP97 MAGEA2 Homo sapiens P43356
Y2H Array
32296183
Intra
DYNLRB1 Q9NP97 DYNC1I2 Homo sapiens Q13409
Validated Y2H
25416956
Intra
DYNLRB1 Q9NP97 DYNC1I2 Homo sapiens Q13409
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Tuberculous Empyema

  • Empyema, Tuberculous

  • Empyema Tuberculous
Vestibular Nystagmus

  • Nystagmus Associated With Disorder Of The Vestibular System
Asphyxiating Thoracic Dystrophy

  • Jeune Thoracic Dystrophy

  • Jeune Syndrome

  • Asphyxiating Thoracic Dysplasia

  • Short-Rib Thoracic Dysplasia With Or Without Polydactyly

  • Thoracic Pelvic Phalangeal Dystrophy

  • Asphyxiating Thoracic Chondrodystrophy

  • Atd

  • Chondroectodermal Dysplasia-Like Syndrome

  • Infantile Thoracic Dystrophy

  • Jeune Thoracic Dysplasia

  • Thoracic Asphyxiant Dystrophy

  • Thoracic-Pelvic-Phalangeal Dystrophy

  • Short-Rib Thoracic Dysplasia Without Polydactyly

  • Asphyxiating Thoracic Dystrophy Of The Newborn

  • Asphyxiating Thorax Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04090 DYNLRB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris DYNLRB1 VGNC VGNC:40152
Bos taurus DYNLRB1 VGNC VGNC:28276
Felis catus DYNLRB1 VGNC VGNC:61682
Macaca mulatta DYNLRB1 VGNC VGNC:71839
Rattus norvegicus DYNLRB1 RGD RGD:619910
Mus musculus DYNLRB1 MGD MGI:1914318
Others DYNLRB1 NCBI