GRPR antagonist-2
GRPR antagonist-2 is a potent gastrin releasing peptide receptor (GRPR) antagonist, having the cytotoxicity against certain cancer cells (IC50 of 0.77 and 2.5 μM in HGC-27 and Pan02 cells, respectively). Anticancer activity.
For research use only. We do not sell to patients.
- CAS No.: 3052544-42-7
- Formula: C28H32F3N5O4
- Molecular Weight:559.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.77 μM (GRPR) in HGC-27, 2.5 μM (GRPR) in Pan02[1]
GRPR antagonist-2 (compound 6e) (0.032-100?μM; 48 hours) has the cytotoxicity against certain cancer cells, also reduces PC3, Pan02, HGC-27, and HepG2 cell viability combined with HDAC inhibitor (1 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC3, HepG2, HGC-27, Pan02, and HK2 cells[1]
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Concentration:0.032-100 μM
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Incubation Time:48 hours
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Result:Showed the cytotoxicity against these cancer cells, also reduced PC3, Pan02, HGC-27, and HepG2 cell viability combined with HDAC inhibitor (1 μM).
Chemical Information
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CAS No. 3052544-42-7
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Molecular Weight 559.58
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Formula C28H32F3N5O4
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SMILES
CC(C)(OC(N1CCN(CC1)C([C@H](CC2=CNC3=C2C=CC=C3)NC(NC4=CC=C(C=C4)C(F)(F)F)=O)=O)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GRPR antagonist-2 Related Classifications
HY-115975 Related Classifications
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