TRC-766
Based on 1 Customer Validation
TRC-766 is a negative control of RTC-5 (TRC-382). TRC-766 binds protein phosphatase 2A (PP2A) and does not activate the phosphatase.
For research use only. We do not sell to patients.
- Purity: 98.07%
- CAS No.: 1810734-44-1
- Formula: C25H24ClF3N2O3S
- Molecular Weight:524.98
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
As a pharmacologic control, the cells are treated with increasing doses of TRC-766, which is structurally similar to PP2A (SMAP) but biologically inactive. TRC-766 lacks a key N-H sulfonamide hydrogen bond donor. While TRC-766 still binds PP2A, it does not activate the phosphatase and therefore it was postulated to not affect cell viability[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1810734-44-1
-
Appearance Solid
-
Molecular Weight 524.98
-
Formula C25H24ClF3N2O3S
-
Color White to off-white
-
SMILES
O=S(C1=CC=C(OC(F)(F)F)C=C1)(N(CCCN2C3=CC(Cl)=CC=C3CCC4=CC=CC=C42)C)=O
-
Synonyms
DBK-766
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 150 mg/mL (285.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (272 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9048 mL | 9.5242 mL | 19.0483 mL | 47.6209 mL |
| 5 mM | 0.3810 mL | 1.9048 mL | 3.8097 mL | 9.5242 mL | |
| 10 mM | 0.1905 mL | 0.9524 mL | 1.9048 mL | 4.7621 mL | |
| 15 mM | 0.1270 mL | 0.6349 mL | 1.2699 mL | 3.1747 mL | |
| 20 mM | 0.0952 mL | 0.4762 mL | 0.9524 mL | 2.3810 mL | |
| 25 mM | 0.0762 mL | 0.3810 mL | 0.7619 mL | 1.9048 mL | |
| 30 mM | 0.0635 mL | 0.3175 mL | 0.6349 mL | 1.5874 mL | |
| 40 mM | 0.0476 mL | 0.2381 mL | 0.4762 mL | 1.1905 mL | |
| 50 mM | 0.0381 mL | 0.1905 mL | 0.3810 mL | 0.9524 mL | |
| 60 mM | 0.0317 mL | 0.1587 mL | 0.3175 mL | 0.7937 mL | |
| 80 mM | 0.0238 mL | 0.1191 mL | 0.2381 mL | 0.5953 mL | |
| 100 mM | 0.0190 mL | 0.0952 mL | 0.1905 mL | 0.4762 mL |
TRC-766 Related Classifications
HY-131443 Related Classifications
Powered by Bioz