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Cat. No.: HY-182672

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VT101

VT101 is a TEAD inhibitor with an IC₅₀ of 454 nM. VT101 is applicable for cancer research.

For research use only. We do not sell to patients.

CAS No.: 65194-64-1
Formula: C₁₄H₂₀N₂O₄S
Molecular Weight:312.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

VT101 Chemical Structure

CAS No.: 65194-64-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

VT101 is a TEAD inhibitor with an IC₅₀ of 454 nM. VT101 is applicable for cancer research^[1].

IC₅₀ & Target

^[1]

TEAD

454 nM (IC₅₀)

All YAP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H2052	IC₅₀	3 μM Compound: 39; VT101	Antiproliferative activity against human NCI-H2052 cells Antiproliferative activity against human NCI-H2052 cells	[PMID: 39047607]

In Vitro

VT101 inhibits YAP-mediated transcriptional activity with an IC₅₀ of 454 nM in a luciferase reporter assay but does not significantly inhibit the growth of NCI-H2052 cells (IC₅₀ > 3 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 65194-64-1
Molecular Weight 312.38
Formula C₁₄H₂₀N₂O₄S
SMILES

O=C(C1=CC(S(=O)(N)=O)=CC=C1NC2CCCCC2)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lou J, et al. A chemical perspective on the modulation of TEAD transcriptional activities: Recent progress, challenges, and opportunities. Eur J Med Chem. 2022;243:114684. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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