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Cat. No.: HY-186175

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DMG-PEG2000-Mal-Cys-penetratin

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DMG-PEG2000-Mal-Cys-penetratin is a conjugate composed of dimyristoylglycerol (DMG), a PEG chain, and terminal maleimide (Mal). DMG-PEG2000-Mal-Cys-penetratin combines the membrane compatibility of lipids, the specific Michael addition reaction with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers) by maleimide, and cell-penetrating peptides, making it suitable for research on biomaterial construction and drug delivery to cells.

For research use only. We do not sell to patients.

Purity: 95.0%

Storage:

-80°C

DMG-PEG2000-Mal-Cys-penetratin Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Bioz

Biological Activity

Description

In Vitro

The structure of DMG-PEG2000-Mal-Cys-penetratin comprises four key components, which work synergistically:
DMG: As a hydrophobic anchor, it is responsible for firmly embedding the entire molecule into the membrane structure of lipid nanoparticles.
PEG chain: As a hydrophilic spacer, it forms a hydration layer on the particle surface, reducing non-specific adsorption and immune system recognition and clearance, thus prolonging the carrier's circulation time in vivo.
Maleimide: Located at the end of the PEG chain, it acts as a reaction interface, undergoing specific Michael addition reactions with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers) to achieve targeting or tracking functions.
Cys-penetratin: Efficiently helps the entire nanoparticle cross the cell membrane and enter the cell to exert its effects.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Appearance Oil
Color Yellow to brown
SMILES

CCCCCCCCCCCCCC(OC(COCCOCCNC(CCN1C(CC(SC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCSC)C(N[C@@H](CCCCN)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)N)C1=O)=O)=O)COC(CCCCCCCCCCCCC)=O)=O.[n]
Shipping

Shipping with dry ice.
Storage

-80°C