DMT-2'-OMe-D-Ribitol phosphoramidite
Based on 1 Customer Validation
DMT-2'-OMe-D-Ribitol phosphoramidite is a phosphoramidite monomer synthesized from (2R,3S,4S)-2-hydroxymethyl-4-methoxytetrahydrofuran-3-ol, used to introduce the Y34 abasic moiety into oligonucleotides for solid-phase oligonucleotide synthesis. DMT-2'-OMe-D-Ribitol phosphoramidite can be used for the research of huntington's disease, machado joseph disease (spinocerebellar ataxia 3).
For research use only. We do not sell to patients.
- Purity: 99.23%
- CAS No.: 1470023-72-3
- Formula: C36H47N2O7P
- Molecular Weight:650.74
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
DMT-2'-OMe-D-Ribitol phosphoramidite (Compound 9) is used to introduce the Y34 abasic moiety into oligonucleotides during solid-phase oligonucleotide synthesis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1470023-72-3
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Appearance Oil
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Molecular Weight 650.74
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Formula C36H47N2O7P
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Color Light yellow to yellow
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SMILES
COC(C=C1)=CC=C1C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@@H]4[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](OC)CO4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (153.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5367 mL | 7.6836 mL | 15.3671 mL | 38.4178 mL |
| 5 mM | 0.3073 mL | 1.5367 mL | 3.0734 mL | 7.6836 mL | |
| 10 mM | 0.1537 mL | 0.7684 mL | 1.5367 mL | 3.8418 mL | |
| 15 mM | 0.1024 mL | 0.5122 mL | 1.0245 mL | 2.5612 mL | |
| 20 mM | 0.0768 mL | 0.3842 mL | 0.7684 mL | 1.9209 mL | |
| 25 mM | 0.0615 mL | 0.3073 mL | 0.6147 mL | 1.5367 mL | |
| 30 mM | 0.0512 mL | 0.2561 mL | 0.5122 mL | 1.2806 mL | |
| 40 mM | 0.0384 mL | 0.1921 mL | 0.3842 mL | 0.9604 mL | |
| 50 mM | 0.0307 mL | 0.1537 mL | 0.3073 mL | 0.7684 mL | |
| 60 mM | 0.0256 mL | 0.1281 mL | 0.2561 mL | 0.6403 mL | |
| 80 mM | 0.0192 mL | 0.0960 mL | 0.1921 mL | 0.4802 mL | |
| 100 mM | 0.0154 mL | 0.0768 mL | 0.1537 mL | 0.3842 mL |
DMT-2'-OMe-D-Ribitol phosphoramidite Related Classifications
HY-160884 Related Classifications
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- DMT-2'-OMe-D-Ribitol phosphoramidite
- 1470023-72-3
- DNA/RNA Synthesis
- Phosphoramidites
- machado joseph disease
- Y34 abasic moiety
- mutant HTT protein
- GM06151 SCA3 fibroblasts
- GM04281 HD fibroblasts
- spinocerebellar ataxia 3
- solid-phase oligonucleotide synthesis
- huntington's disease
- oligonucleotides
- mutant ATX-3 protein
- Inhibitor
- inhibitor
- inhibit