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Cat. No.: HY-155288

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DosatiLink-1

DosatiLink-1 is an Abelson murine leukemia (ABL) enzyme inhibitor.

For research use only. We do not sell to patients.

CAS No.: 2941512-37-2
Formula: C₆₉H₉₃Cl₂F₂N₁₃O₁₇S
Molecular Weight:1517.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

DosatiLink-1 Chemical Structure

CAS No.: 2941512-37-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

DosatiLink-1 is an Abelson murine leukemia (ABL) enzyme inhibitor^[1].

All Bcr-Abl Isoforms :

Abl
Bcr-Abl

Cellular Effect

Cell Line	Type	Value	Description	References
K562	EC₅₀	>300 nM Compound: Dosati Link-1	Antiproliferative activity against human K562 cells expressing ABL T315I mutant assessed as inhibition of cell growth incubated for 3 days by celltiter-glo 2.0 assay Antiproliferative activity against human K562 cells expressing ABL T315I mutant assessed as inhibition of cell growth incubated for 3 days by celltiter-glo 2.0 assay	[PMID: 37849551]
K562	EC₅₀	2.47 nM Compound: Dosati Link-1	Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 3 days by celltiter-glo 2.0 assay Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 3 days by celltiter-glo 2.0 assay	[PMID: 37849551]

Chemical Information

CAS No. 2941512-37-2
Molecular Weight 1517.52
Formula C₆₉H₉₃Cl₂F₂N₁₃O₁₇S
SMILES

O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(C1CCN(C2=C(C3=CC=NN3)C=C(C(NC4=CC=C(OC(F)(Cl)F)C=C4)=O)C=N2)CC1)=O)N5CCN(C6=CC(NC7=NC=C(C(NC8=C(Cl)C=CC=C8C)=O)S7)=NC(C)=N6)CC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Robert B. Kargbo. Expanding the Chemical Space: New Approach to Cell-Permeable Drugs. ACS Med. Chem. Lett. 2023, 14, 10, 1329-1330.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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DosatiLink-1

All Bcr-Abl Isoforms