DPPE-PEG2000-CGKRK

DPPE-PEG2000-CGKRK is composed of three covalently linked components: 1. DPPE (1,2-dipalmitoyl-sn-glycerol-3-phosphate ethanolamine): Lipid anchoring group-inserts into the lipid bilayer of liposomes/LNPs, providing stable membrane anchoring; its saturated C16 chain imparts bilayer rigidity. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing steric separation between the lipid surface and the targeting ligand. 3. CGKRK peptide: Targeting/functional ligand-CGKRK peptide is a tumor angiogenesis-targeting peptide rich in basic amino acids that specifically binds to heparan sulfate on the surface of tumor vascular endothelial cells, achieving dual targeting of tumor cells and tumor angiogenesis.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.