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Cat. No.: HY-187782A

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DPPE-PEG2000-WLSEAGPVVTVRALRGTGSW

DPPE-PEG2000-WLSEAGPVVTVRALRGTGSW is a functionalized PEGylated phospholipid conjugate composed of three modular components: 1,2-dispalmitoyl-sn-glycerol-3-phosphoethanolamine (DPPE) as a lipid anchoring group, a 2000 Da polyethylene glycol (PEG) spacer arm, and the WLSEAGPVVTVRALRGTGSW (HY-P3436) peptide as a terminal targeting/functional ligand. DPPE-PEG2000-WLSEAGPVVTVRALRGTGSW can be used in research on targeted drug delivery for cardiovascular diseases (such as myocardial infarction and heart failure).

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DPPE-PEG2000-WLSEAGPVVTVRALRGTGSW Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

In Vitro

DPPE-PEG2000-WLSEAGPVVTVRALRGTGSW is composed of three covalently linked components: 1. DPPE (1,2-dipalmitoyl-sn-glycerol-3-phosphoethanolamine): A lipid anchoring group that inserts into the lipid bilayer of liposomes/LNPs, providing stable membrane anchoring; its saturated C16 chain imparts bilayer rigidity. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): A hydrophilic polymer spacer arm that forms a steric hindrance crown around the nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing steric separation between the lipid surface and the targeting ligand. 3. WLSEAGPVVTVRALRGTGSW peptide: A cardiomyocyte-targeting peptide that specifically recognizes tenosynovin X on the surface of cardiomyocytes.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

SMILES

[DPPE-PEG2000-WLSEAGPVVTVRALRGTGSW]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gu J, et al. Engineered bone marrow mesenchymal stem cell-derived exosomes loaded with miR302 through the cardiomyocyte specific peptide can reduce myocardial ischemia and reperfusion (I/R) injury. Journal of translational medicine. 2024 Feb 17;22(1):168. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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