[DPro10] Dynorphin A (1-11), porcine hydrochloride
[DPro10] Dynorphin A (1-11), porcine hydrochloride, a N-Alkylated derivative, is a potent κ-opioid receptor agonist with a Ki value of 0.13 nM. [DPro10] Dynorphin A (1-11), porcine hydrochloride has analgesic property.
For research use only. We do not sell to patients.
- Formula: C63H103N21O13.xHCl
- Molecular Weight:1362.62 (free acid)
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
![[DPro10] Dynorphin A (1-11), porcine hydrochloride Chemical Structure](https://file.medchemexpress.com/product_pic/hy-p3647a.gif "Click to View [DPro10] Dynorphin A (1-11), porcine hydrochloride Chemical Structure")
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Opioid Receptor Isoforms
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Biological Activity
Description
In Vitro
[DPro10] Dynorphin A (1-11), porcine has inhibition of adenylyl cyclase activity in k-opioid receptor-expressing CHO cells with an IC50 value of 0.12 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 1362.62 (free acid)
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Formula C63H103N21O13.xHCl
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Sequence
Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-{d-Pro}-Lys
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Sequence Shortening
YGGFLRRIR-{d-Pro}-K
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Soderstrom K, et, al. N-alkylated derivatives of [D-Pro10]dynorphin A-(1-11) are high affinity partial agonists at the cloned rat kappa-opioid receptor. Eur J Pharmacol. 1997 Nov 5;338(2):191-7. [Content Brief]
[2]. Gairin JE, et, al. [D-Pro10]-dynorphin(1-11) is a kappa-selective opioid analgesic in mice. J Pharmacol Exp Ther. 1988 Jun;245(3):995-1001. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
[DPro10] Dynorphin A (1-11), porcine hydrochloride Related Classifications
HY-P3647A Related Classifications
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