[DPro10] Dynorphin A (1-11), porcine hydrochloride
[DPro10] Dynorphin A (1-11), porcine hydrochloride, a N-Alkylated derivative, is a potent κ-opioid receptor agonist with a Ki value of 0.13 nM. [DPro10] Dynorphin A (1-11), porcine hydrochloride has analgesic property.
For research use only. We do not sell to patients.
- Formula: C63H103N21O13.xHCl
- Molecular Weight:1362.62 (free acid)
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
![[DPro10] Dynorphin A (1-11), porcine hydrochloride Chemical Structure](https://file.medchemexpress.com/product_pic/hy-p3647a.gif "Click to View [DPro10] Dynorphin A (1-11), porcine hydrochloride Chemical Structure")
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Opioid Receptor Isoforms
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Biological Activity
Description
In Vitro
[DPro10] Dynorphin A (1-11), porcine has inhibition of adenylyl cyclase activity in k-opioid receptor-expressing CHO cells with an IC50 value of 0.12 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 1362.62 (free acid)
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Formula C63H103N21O13.xHCl
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Sequence
Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-{d-Pro}-Lys
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Sequence Shortening
YGGFLRRIR-{d-Pro}-K
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Soderstrom K, et, al. N-alkylated derivatives of [D-Pro10]dynorphin A-(1-11) are high affinity partial agonists at the cloned rat kappa-opioid receptor. Eur J Pharmacol. 1997 Nov 5;338(2):191-7. [Content Brief]
[2]. Gairin JE, et, al. [D-Pro10]-dynorphin(1-11) is a kappa-selective opioid analgesic in mice. J Pharmacol Exp Ther. 1988 Jun;245(3):995-1001. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
[DPro10] Dynorphin A (1-11), porcine hydrochloride Related Classifications
HY-P3647A Related Classifications
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