[DPro10] Dynorphin A (1-11), porcine hydrochloride

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[DPro10] Dynorphin A (1-11), porcine hydrochloride, a N-Alkylated derivative, is a potent κ-opioid receptor agonist with a K_i value of 0.13 nM. [DPro10] Dynorphin A (1-11), porcine hydrochloride has analgesic property.

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[DPro10] Dynorphin A (1-11), porcine hydrochloride Estructura química

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50 mg		Obtener un presupuesto
100 mg		Obtener un presupuesto
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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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Descripciòn	[DPro10] Dynorphin A (1-11), porcine hydrochloride, a N-Alkylated derivative, is a potent κ-opioid receptor agonist with a K_i value of 0.13 nM. [DPro10] Dynorphin A (1-11), porcine hydrochloride has analgesic property^[1]^[2].
In Vitro	[DPro10] Dynorphin A (1-11), porcine has inhibition of adenylyl cyclase activity in k-opioid receptor-expressing CHO cells with an IC₅₀ value of 0.12 nM^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. [DPro10] Dynorphin A (1-11), porcine hydrochloride Related Antibodies
In Vivo	[DPro10] Dynorphin A (1-11), porcine (ICV) has analgesic effects involving thermal cutaneous (tail-flick) and chemical visceral (AcOH-induced writhing) stimuli, in which mu and kappa receptors are known to be activated differentially^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Peso molecular	1362.62 (free acid)
Fòrmula	C₆₃H₁₀₃N₂₁O₁₃.xHCl
Sequence	Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-{d-Pro}-Lys
Sequence Shortening	YGGFLRRIR-{d-Pro}-K
Envío	Room temperature in continental US; may vary elsewhere.
Almacenamiento	Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación	Ficha de datos (269 KB) Instrucciones de manejo (2659 KB)
Referencias	[1]. Soderstrom K, et, al. N-alkylated derivatives of [D-Pro10]dynorphin A-(1-11) are high affinity partial agonists at the cloned rat kappa-opioid receptor. Eur J Pharmacol. 1997 Nov 5;338(2):191-7. [Content Brief] [2]. Gairin JE, et, al. [D-Pro10]-dynorphin(1-11) is a kappa-selective opioid analgesic in mice. J Pharmacol Exp Ther. 1988 Jun;245(3):995-1001. [Content Brief]