1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol
1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol (DSPG) is an anionic (negatively charged) phospholipid. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol is used to prepare lipid microbubbles as ultrasound contrast agents. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol can be used to construct liposomes as vaccine carriers for the treatment of atherosclerosis. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol is applicable to the research of drug delivery and diagnostic preparations.
For research use only. We do not sell to patients.
- CAS No.: 217939-97-4
- Formula: C42H83O10P
- Molecular Weight:779.08
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol forms part of the protein corona of liposomes and mediates the uptake by antigen-presenting cells[1].
When incorporated at a ratio of 60%, 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol enhances the stability of lipid-based microbubble shells, which helps prolong in vivo blood flow imaging duration and reduce hepatic uptake[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 217939-97-4
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Molecular Weight 779.08
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Formula C42H83O10P
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SMILES
OCC(O)COP(OC[C@@H](COC(CCCCCCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCCCCCC)=O)(O)=O
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Synonyms
DSPG
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Cardiovascular Diseases
Cardiovascular disease can be modeled as maladaptive cardiac remodeling, where ischemic injury or pressure overload activates inflammatory signaling, fibroblast activation, extracellular-matrix deposition, cardiomyocyte hypertrophy, vascular remodeling, and progressive ventricular dysfunction. The TGF-β/SMAD axis is a central profibrotic pathway after myocardial injury and pressure overload, while innate immune and cytokine pathways regulate leukocyte recruitment, scar formation, and adverse remodeling. Key unresolved questions include which inflammatory signals are reparative versus harmful, when fibrosis is protective versus maladaptive, and whether pathway inhibition improves function without weakening necessary infarct healing or compensatory remodeling.
Purity & Documentation
References
[1]. Benne N, et al. Anionic 1,2-distearoyl-sn-glycero-3-phosphoglycerol (DSPG) liposomes induce antigen-specific regulatory T cells and prevent atherosclerosis in mice. J Control Release. 2018;291:135-146. [Content Brief]
[2]. Maruyama T, et al. Effect of lipid shell composition in DSPG-based microbubbles on blood flow imaging with ultrasonography. Int J Pharm. 2020;590:119886. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol Related Classifications
HY-148601 Related Classifications
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