2. Protein Tyrosine Kinase/RTK
  3. DYRK
  4. DYRKs-IN-2

DYRKs-IN-2 (Example 132) is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively. DYRKs-IN-2 has antitumor activity.

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DYRKs-IN-2

DYRKs-IN-2 Estructura química

No. CAS : 1386980-04-6

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DYRKs-IN-2 Related Antibodies

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DYRK1 DYRK2 DYRK3 DYRK4 HIPK PRP4

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Descripciòn

DYRKs-IN-2 (Example 132) is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively. DYRKs-IN-2 has antitumor activity[1].

IC50 & Target

IC50: 30.6 nM (DYRK1B) and 12.8 nM (DYRK1A)[2]
Cellular Effect
Cell Line Type Value Description References
SW-620 EC50
0.18 μM
Compound: 27
Cytotoxicity against human SW620 cells
Cytotoxicity against human SW620 cells
[PMID: 24239188]
In Vitro

DYRKs-IN-2 (Example 132) has an EC50 of 22.8 nM for SW620 cell line[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DYRKs-IN-2 Related Antibodies
Peso molecular

632.16

Fòrmula

C32H38ClN9O3
No. CAS
SMILES

O=C(C1=CC2=CN=C(NCCCN3CCN(C)CC3)N=C2NC1=O)NC4=CC(C(NC(C5=CC=CC=C5)CCN)=O)=CC=C4Cl
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

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Referencias
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DYRKs-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DYRKs-IN-21386980-04-6DYRKDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseInhibitorinhibitorinhibit

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Nombre del producto:
DYRKs-IN-2
Cat. No.:
HY-128759
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