2. Protein Tyrosine Kinase/RTK
  3. DYRK
  4. DYRKs-IN-2

DYRKs-IN-2 (Example 132) is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively. DYRKs-IN-2 has antitumor activity.

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DYRKs-IN-2

DYRKs-IN-2 화학구조

CAS No. : 1386980-04-6

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DYRKs-IN-2 Related Antibodies

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DYRK1 DYRK2 DYRK3 DYRK4 HIPK PRP4

  • Biological Activity

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제품 설명

DYRKs-IN-2 (Example 132) is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively. DYRKs-IN-2 has antitumor activity[1].

IC50 & Target

IC50: 30.6 nM (DYRK1B) and 12.8 nM (DYRK1A)[2]
Cellular Effect
Cell Line Type Value Description References
SW-620 EC50
0.18 μM
Compound: 27
Cytotoxicity against human SW620 cells
Cytotoxicity against human SW620 cells
[PMID: 24239188]
In Vitro

DYRKs-IN-2 (Example 132) has an EC50 of 22.8 nM for SW620 cell line[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DYRKs-IN-2 Related Antibodies
분자량

632.16

화학식

C32H38ClN9O3
CAS No.
SMILES

O=C(C1=CC2=CN=C(NCCCN3CCN(C)CC3)N=C2NC1=O)NC4=CC(C(NC(C5=CC=CC=C5)CCN)=O)=CC=C4Cl
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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DYRKs-IN-2 Related Classifications

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  • 농도 희석 계산기

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DYRKs-IN-21386980-04-6DYRKDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseInhibitorinhibitorinhibit

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상품명:
DYRKs-IN-2
Cat. No.:
HY-128759
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