EGFR T790M/L858R-IN-9
EGFR T790M/L858R-IN-9 (Compound 8) is an EGFR-L858R/T790M inhibitor that demonstrates potent inhibitory phosphorylation effects against the EGFR-L858R/T790M mutant kinase, with an IC50 value of 0.0064µM. EGFR T790M/L858R-IN-9 also inhibits the proliferation of non-small cell lung cancer (NSCLC) cells and can be utilized in cancer research.
For research use only. We do not sell to patients.
- Formula: C26H27N7O3S
- Molecular Weight:517.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 0.0064 μM (EGFRT-790M/L858R)[1].
EGFR T790M/L858R-IN-9 (Compound 8) exhibits antiproliferative activity in both mutant and wild-type NSCLC cell lines, with IC50 values of 0.170 μM (for proliferation of H1975 cells harboring the EGFR-L858R/T790M mutation) and 0.554 μM (for A549 cells), respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 517.60
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Formula C26H27N7O3S
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SMILES
COC1=CC=C(C2=NN=C(NC3=NC(OC4=CC(N5CCN(C(CC)=O)CC5)=CC=C4)=NC=C3)S2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR T790M/L858R-IN-9 Related Classifications
HY-170665 Related Classifications
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