endo-BCN-PEG2-PFP ester

Name: endo-BCN-PEG2-PFP ester
Brand: MedChemExpress
SKU: HY-140072
Rating: 4.5 (1 reviews)

Cat. No.: HY-140072 Purity: 95.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

endo-BCN-PEG2-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. endo-BCN-PEG2-PFP ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

For research use only. We do not sell to patients.

endo-BCN-PEG2-PFP ester Chemical Structure

CAS No. : 1421932-53-7

Size	Stock	Quantity
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

endo-BCN-PEG2-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. endo-BCN-PEG2-PFP ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC₅₀ & Target

PEGs	Alkyl/ether

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

519.46

Formula

C₂₄H₂₆F₅NO₆

CAS No.

1421932-53-7

Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(OC1=C(F)C(F)=C(F)C(F)=C1F)CCOCCOCCNC(OCC2C3CCC#CCCC23)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : ≥ 125 mg/mL (240.63 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9251 mL	9.6254 mL	19.2508 mL
5 mM	0.3850 mL	1.9251 mL	3.8502 mL
10 mM	0.1925 mL	0.9625 mL	1.9251 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

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In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.0%

Select Batch:

Data Sheet (268 KB) SDS (252 KB)

COA (243 KB) HNMR (198 KB) MS (70 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9251 mL	9.6254 mL	19.2508 mL	48.1269 mL
	5 mM	0.3850 mL	1.9251 mL	3.8502 mL	9.6254 mL
	10 mM	0.1925 mL	0.9625 mL	1.9251 mL	4.8127 mL
	15 mM	0.1283 mL	0.6417 mL	1.2834 mL	3.2085 mL
	20 mM	0.0963 mL	0.4813 mL	0.9625 mL	2.4063 mL
	25 mM	0.0770 mL	0.3850 mL	0.7700 mL	1.9251 mL
	30 mM	0.0642 mL	0.3208 mL	0.6417 mL	1.6042 mL
	40 mM	0.0481 mL	0.2406 mL	0.4813 mL	1.2032 mL
	50 mM	0.0385 mL	0.1925 mL	0.3850 mL	0.9625 mL
	60 mM	0.0321 mL	0.1604 mL	0.3208 mL	0.8021 mL
	80 mM	0.0241 mL	0.1203 mL	0.2406 mL	0.6016 mL
	100 mM	0.0193 mL	0.0963 mL	0.1925 mL	0.4813 mL