2. PROTAC
  3. PROTAC Linkers
  4. endo-BCN-PEG3-mal

endo-BCN-PEG3-mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. endo-BCN-PEG3-mal is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

For research use only. We do not sell to patients.

endo-BCN-PEG3-mal Chemical Structure

endo-BCN-PEG3-mal Chemical Structure

CAS No. : 2141976-33-0

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1 mg USD 110 In-stock
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10 mg USD 400 In-stock
25 mg USD 800 In-stock
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Based on 1 publication(s) in Google Scholar

endo-BCN-PEG3-mal Related Antibodies

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  • Purity & Documentation

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Description

endo-BCN-PEG3-mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. endo-BCN-PEG3-mal is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

endo-BCN-PEG3-mal Related Antibodies
Molecular Weight

519.59

Formula

C26H37N3O8
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C(OC[C@H]1[C@@]2([H])CCC#CCC[C@@]12[H])NCCOCCOCCOCCNC(CCN3C(C=CC3=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (192.46 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9246 mL 9.6230 mL 19.2459 mL
5 mM 0.3849 mL 1.9246 mL 3.8492 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.00%

COA (243 KB) HNMR (288 KB) LCMS (122 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9246 mL 9.6230 mL 19.2459 mL 48.1149 mL
5 mM 0.3849 mL 1.9246 mL 3.8492 mL 9.6230 mL
10 mM 0.1925 mL 0.9623 mL 1.9246 mL 4.8115 mL
15 mM 0.1283 mL 0.6415 mL 1.2831 mL 3.2077 mL
20 mM 0.0962 mL 0.4811 mL 0.9623 mL 2.4057 mL
25 mM 0.0770 mL 0.3849 mL 0.7698 mL 1.9246 mL
30 mM 0.0642 mL 0.3208 mL 0.6415 mL 1.6038 mL
40 mM 0.0481 mL 0.2406 mL 0.4811 mL 1.2029 mL
50 mM 0.0385 mL 0.1925 mL 0.3849 mL 0.9623 mL
60 mM 0.0321 mL 0.1604 mL 0.3208 mL 0.8019 mL
80 mM 0.0241 mL 0.1203 mL 0.2406 mL 0.6014 mL
100 mM 0.0192 mL 0.0962 mL 0.1925 mL 0.4811 mL
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endo-BCN-PEG3-mal Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

endo-BCN-PEG3-mal2141976-33-0PROTAC LinkersInhibitorinhibitorinhibit

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