Eoxin E4
Eoxin E4 (14,15-LTE4) is the metabolite of 14,15-LTC4 and 14,15-LTD4. Eoxin E4 increases vascular permeability of human endothelial cell monolayers with about 10-fold less potency than LTC4, but approximately 100-fold greater potency than histamine.
For research use only. We do not sell to patients.
- CAS No.: 1000852-57-2
- Formula: C23H37NO5S
- Molecular Weight:439.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-130429
14,15-Leukotriene C4Leukotrienes -
HY-113483
20-Carboxy-Leukotriene B4LTB4 Metabolite -
HY-B0802A
Terbutalineβ2-Drenergic Receptor Agonist -
HY-120954
14,15-EE-5(Z)-E14,15-EET structural analogue -
HY-130497
12-Oxo-leukotriene B4Endogenous Metabolite -
HY-113884B
(S)-Coriolic acidPPARγ Activator/Mitochondrial Dysfunction Inducer -
HY-112621
Leukotriene A4 methyl ester -
HY-113479
20-Hydroxy-leukotriene B4Endogenous Metabolite -
HY-130440
Leukotriene F4Arachidonic Metabolite -
HY-113509B
15(R)-Lipoxin A4Specialized Pro-resolving Mediator -
HY-113490
15-KETE -
HY-113492
5(S)15(S)-DiHETEPlatelet Aggregation Inhibitor
Biological Activity
Description
Chemical Information
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CAS No. 1000852-57-2
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Molecular Weight 439.61
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Formula C23H37NO5S
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SMILES
CCCCC[C@@H]([C@@H](/C=C/C=C/C=C\C/C=C\CCCC(O)=O)SC[C@@H](C(O)=O)N)O
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Synonyms
14,15-LTE4; EoxE4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Transepithelial/transendothelial electrical resistance assay
TEER measures electrical resistance across epithelial or endothelial monolayers cultured on permeable supports, and the readout reflects ionic conductance through the cell barrier, especially the paracellular pathway regulated by junctional integrity. TEER can be measured without destroying the monolayer and is commonly used before or during transport, permeability, barrier-disruption, and barrier-maturation experiments. TEER values are influenced by biological maturation and technical conditions; reported factors include temperature, medium formulation, passage number, electrode geometry, membrane properties, and junctional length during early monolayer maturation. Therefore, TEER should be interpreted with blank-insert subtraction, area normalization, repeated readings, and, when possible, orthogonal barrier readouts such as FITC-dextran flux or tight-junction staining.
Purity & Documentation
References
[1]. Bryant RW, et al. Leukotriene formation by a purified reticulocyte lipoxygenase enzyme. Conversion of arachidonic acid and 15-hydroperoxyeicosatetraenoic acid to 14, 15-leukotriene A4. J Biol Chem. 1985 Mar 25;260(6):3548-55. [Content Brief]
[2]. Luo M, et al. Leukotriene synthesis by epithelial cells. Histol Histopathol. 2003 Apr;18(2):587-95. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Eoxin E4 Related Classifications
HY-115356 Related Classifications
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