2. MAPK/ERK Pathway Stem Cell/Wnt
  3. ERK
  4. ERK2-IN-4

ERK2-IN-4 (Compound 6o) is an effective and selective ERK2 inhibitor with a Ki of 0.006 μM. ERK2-IN-4 inhibits the ERK signaling pathway and can be used in cancer research.

For research use only. We do not sell to patients.

ERK2-IN-4

ERK2-IN-4 Chemical Structure

CAS No. : 933786-58-4

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Based on 1 publication(s) in Google Scholar

ERK2-IN-4 Related Antibodies

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ERK ERK1 ERK2 ERK5 ERK8

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Description

ERK2-IN-4 (Compound 6o) is an effective and selective ERK2 inhibitor with a Ki of 0.006 μM. ERK2-IN-4 inhibits the ERK signaling pathway and can be used in cancer research[1].

IC50 & Target

ERK2

0.006 μM (Ki)

Molecular Weight

459.30

Formula

C22H17Cl2FN4O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OCC(C1=CC=C(C(Cl)=C1)F)NC(C2=CC(C(NN=C3)=C3C4=CC(Cl)=CC=C4)=CN2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 5 mg/mL (10.89 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1772 mL 10.8861 mL 21.7723 mL
5 mM 0.4354 mL 2.1772 mL 4.3545 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.9%

SDS (252 KB)

COA (256 KB) RP-HPLC (107 KB) MS (178 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 2.1772 mL 10.8861 mL 21.7723 mL 54.4307 mL
5 mM 0.4354 mL 2.1772 mL 4.3545 mL 10.8861 mL
10 mM 0.2177 mL 1.0886 mL 2.1772 mL 5.4431 mL
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ERK2-IN-4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ERK2-IN-4933786-58-4ERKExtracellular signal regulated kinasespyrazolylpyrroleInhibitorinhibitorinhibit

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