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Cat. No.: HY-114602

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AR-C117977

AR-C117977 is a potent monocarboxylate transporter (MCT1) inhibitor. AR-C117977 prolongs the survival of skin and heart sllograft. AR-C117977 inhibits the development of transplant arteriosclerosis in aortic allografts partially, but was unable to inhibit alloantibody production after transplantation. AR-C117977 shows potent immunosuppressive properties in vivo effectively preventing acute but not chronic allograft rejection in the mouse.

For research use only. We do not sell to patients.

CAS No.: 216685-07-3
Formula: C₂₅H₂₈N₂O₃S₂
Molecular Weight:468.63

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

AR-C117977 Chemical Structure

CAS No.: 216685-07-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Monocarboxylate Transporter Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against HEK293 cells assessed as inhibition of cell proliferation by fluorimetric assay Antiproliferative activity against HEK293 cells assessed as inhibition of cell proliferation by fluorimetric assay	[PMID: 16370372]
HT-29	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation by fluorimetric assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation by fluorimetric assay	[PMID: 16370372]
HUVEC	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human HUVEC assessed as inhibition of basic FGF-stimulated cell proliferation by fluorimetric assay Antiproliferative activity against human HUVEC assessed as inhibition of basic FGF-stimulated cell proliferation by fluorimetric assay	[PMID: 16370372]
HUVEC	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human HUVEC assessed as inhibition of acidic FGF-stimulated cell proliferation by fluorimetric assay Antiproliferative activity against human HUVEC assessed as inhibition of acidic FGF-stimulated cell proliferation by fluorimetric assay	[PMID: 16370372]
K562	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation by fluorimetric assay Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation by fluorimetric assay	[PMID: 16370372]
Keratinocyte	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human primary epidermal keratinocytes assessed as inhibition of cell proliferation by fluorimetric assay Antiproliferative activity against human primary epidermal keratinocytes assessed as inhibition of cell proliferation by fluorimetric assay	[PMID: 16370372]
PANC-1	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human PANC1 cells assessed as inhibition of cell proliferation by fluorimetric assay Antiproliferative activity against human PANC1 cells assessed as inhibition of cell proliferation by fluorimetric assay	[PMID: 16370372]
SW480	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human SW480 cells assessed as inhibition of cell proliferation by fluorimetric assay Antiproliferative activity against human SW480 cells assessed as inhibition of cell proliferation by fluorimetric assay	[PMID: 16370372]
T-24	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human T24 cells assessed as inhibition of cell proliferation by fluorimetric assay Antiproliferative activity against human T24 cells assessed as inhibition of cell proliferation by fluorimetric assay	[PMID: 16370372]
THP-1	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human THP1 cells assessed as inhibition of cell proliferation by fluorimetric assay Antiproliferative activity against human THP1 cells assessed as inhibition of cell proliferation by fluorimetric assay	[PMID: 16370372]
ZR-75-1	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human ZR-75-1 cells assessed as inhibition of cell proliferation by fluorimetric assay Antiproliferative activity against human ZR-75-1 cells assessed as inhibition of cell proliferation by fluorimetric assay	[PMID: 16370372]

Chemical Information

CAS No. 216685-07-3
Molecular Weight 468.63
Formula C₂₅H₂₈N₂O₃S₂
SMILES

O=C1N(CC(C)C)C2=C(C(SCCCO)=C(CC3=C4C=CC=CC4=CC=C3)S2)C(N1C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bueno V, et al. The specific monocarboxylate transporter (MCT1) inhibitor, AR-C117977, a novel immunosuppressant, prolongs allograft survival in the mouse. Transplantation. 2007 Nov 15;84(9):1204-7. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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